Ethyl 4-bromo-3-methylbenzoate

Base Information

• Chemical Name: Ethyl 4-bromo-3-methylbenzoate
• CAS No.: 160313-69-9
• Molecular Formula: C10H11BrO2
• Molecular Weight: 243.1
• Hs Code.: 2916399090
• Mol file: 160313-69-9.mol

Synonyms:4-bromo-3-methyl-benzoic acid acetate;

Chemical Property of Ethyl 4-bromo-3-methylbenzoate

Chemical Property:

• Appearance/Colour: white crystalline power
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.538
• Boiling Point: 302.573 °C at 760 mmHg
• Flash Point: 136.792 °C
• PSA: 26.30000
• Density: 1.379 g/cm³
• LogP: 2.93420
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 4-Bromo-3-methylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 4-bromo-3-methylbenzoate

There total 2 articles about Ethyl 4-bromo-3-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethanol (64-17-5) + 4-bromo-3-methylbenzoic acid (7697-28-1) → ethyl 3-methyl-4-bromobenzoate (160313-69-9)

Guidance literature:

With thionyl chloride; at 83 ℃; for 6h;

Reference yield:

→ ethyl 3-methyl-4-bromobenzoate (160313-69-9)

Guidance literature:

Reference yield: 70.0%

ethyl 3-methyl-4-bromobenzoate (160313-69-9) → 4-bromo-3-methylbenzylalcohol (149104-89-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 0.75h; Inert atmosphere; Cooling;

upstream raw materials:

ethanol

4-bromo-3-methylbenzoic acid

Downstream raw materials:

2-<(2'-bromo-5'-ethoxycarbonyl)phenyl>-1,3-dioxolane

2-<<2'-bromo-5'-(2''-hydroxyethoxy)carbonyl>phenyl>-1,3-dioxolane

2-[(2'-bromo-5'-hydroxymethyl)phenyl]-1,3-dioxolane

2-(2'-bromo-5'-t-butyldimethylsiloxymethyl)phenyl-1,3-dioxolane

Refernces

• 1、 -. "A stable isotope-labeled diphenyl sulfonamide pharmaceutical preparation method". Paragraph 0031; 0032. . Retrieved 2017/09/21.
• 2、 -. "HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS". Page/Page column 10. . Retrieved 2010/04/25.