(R)-2-[2-(2-Acetylamino-acetylamino)-acetylamino]-3-benzylsulfanyl-N-({[((R)-2-benzylsulfanyl-1-{[(carbamoylmethyl-carbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-propionamide

Base Information

Chemical Name:(R)-2-[2-(2-Acetylamino-acetylamino)-acetylamino]-3-benzylsulfanyl-N-({[((R)-2-benzylsulfanyl-1-{[(carbamoylmethyl-carbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-propionamide
CAS No.:65710-06-7
Molecular Formula:C₃₄H₄₅N₉O₉S₂
Molecular Weight:787.918
Hs Code.:

(R)-2-[2-(2-Acetylamino-acetylamino)-acetylamino]-3-benzylsulfanyl-N-({[((R)-2-benzylsulfanyl-1-{[(carbamoylmethyl-carbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-propionamide

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Chemical Property of (R)-2-[2-(2-Acetylamino-acetylamino)-acetylamino]-3-benzylsulfanyl-N-({[((R)-2-benzylsulfanyl-1-{[(carbamoylmethyl-carbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-propionamide

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Technology Process of (R)-2-[2-(2-Acetylamino-acetylamino)-acetylamino]-3-benzylsulfanyl-N-({[((R)-2-benzylsulfanyl-1-{[(carbamoylmethyl-carbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-propionamide

There total 7 articles about (R)-2-[2-(2-Acetylamino-acetylamino)-acetylamino]-3-benzylsulfanyl-N-({[((R)-2-benzylsulfanyl-1-{[(carbamoylmethyl-carbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 5687-48-9
(2-acetylaminoacetylamino)acetic acid

: 75509-35-2
(R)-2-Amino-3-benzylsulfanyl-N-({[((R)-2-benzylsulfanyl-1-{[(carbamoylmethyl-carbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-propionamide; hydrobromide

: 65710-06-7
(R)-2-[2-(2-Acetylamino-acetylamino)-acetylamino]-3-benzylsulfanyl-N-({[((R)-2-benzylsulfanyl-1-{[(carbamoylmethyl-carbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-propionamide

Guidance literature:: With triethylamine; isobutyl chloroformate; In N,N-dimethyl-formamide; 1.) -10 deg C, 1h 2.) rooom temperature, overnight;
DOI:10.1039/DT9800001228

Reference yield:

: 3401-57-8
N-benzyloxycarbonyl-S-benzyl-L-cysteine succinimido-ester

: 65710-06-7
(R)-2-[2-(2-Acetylamino-acetylamino)-acetylamino]-3-benzylsulfanyl-N-({[((R)-2-benzylsulfanyl-1-{[(carbamoylmethyl-carbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / dioxane / 24 h / Ambient temperature

2: 91 percent / 45percent HBr / acetic acid / 0.83 h / 20 °C

3: 70 percent / dioxane / 24 h / Ambient temperature

4: 85 percent / 45percent HBr / acetic acid / 0.83 h / 20 °C

5: 70 percent / 1.) isobutyl chloroformate, triethylamine / dimethylformamide / 1.) -10 deg C, 1h 2.) rooom temperature, overnight

With hydrogen bromide; triethylamine; isobutyl chloroformate; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1039/DT9800001228

Reference yield:

: 75509-30-7
N-benzyloxycarbonyl-S-benzyl-L-cysteinylglycylglycine

: 65710-06-7
(R)-2-[2-(2-Acetylamino-acetylamino)-acetylamino]-3-benzylsulfanyl-N-({[((R)-2-benzylsulfanyl-1-{[(carbamoylmethyl-carbamoyl)-methyl]-carbamoyl}-ethylcarbamoyl)-methyl]-carbamoyl}-methyl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / N,N'-dicyclohexylcarbodi-imide / dimethylformamide / 24 h / 0 - 25 °C

2: 70 percent / dioxane / 24 h / Ambient temperature

3: 85 percent / 45percent HBr / acetic acid / 0.83 h / 20 °C

4: 70 percent / 1.) isobutyl chloroformate, triethylamine / dimethylformamide / 1.) -10 deg C, 1h 2.) rooom temperature, overnight

With hydrogen bromide; triethylamine; dicyclohexyl-carbodiimide; isobutyl chloroformate; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1039/DT9800001228