5-METHOXY-3-OXO-PENTANOIC ACID ETHYL ESTER

Base Information

• Chemical Name: 5-METHOXY-3-OXO-PENTANOIC ACID ETHYL ESTER
• CAS No.: 104629-86-9
• Molecular Formula: C8H14O4
• Molecular Weight: 174.197
• Hs Code.: 2918990090
• Mol file: 104629-86-9.mol

Synonyms:ethyl 5-methoxy-3-oxopentanoate;

Chemical Property of 5-METHOXY-3-OXO-PENTANOIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.064mmHg at 25°C
• Boiling Point: 230.869°C at 760 mmHg
• Flash Point: 93.382°C
• PSA: 52.60000
• Density: 1.04g/cm³
• LogP: 0.54520
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-Methoxy-3-oxopentanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHOXY-3-OXO-PENTANOIC ACID ETHYL ESTER

There total 3 articles about 5-METHOXY-3-OXO-PENTANOIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.5%

3-Methoxypropionitrile (110-67-8) + ethyl bromoacetate (105-36-2) → 5-methoxy-3-oxopentanic acid ethyl ester (104629-86-9)

Guidance literature:

With hydrogenchloride; Zn/Cu; In tetrahydrofuran;

Reference yield: 73.0%

3-Methoxypropionic acid (2544-06-1) + ethyl potassium malonate (6148-64-7) → 5-methoxy-3-oxopentanic acid ethyl ester (104629-86-9)

Guidance literature:

ethyl potassium malonate; With magnesium chloride hydrate; triethylamine; In acetonitrile; at 20 ℃; for 1h; Inert atmosphere;

3-Methoxypropionic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; for 16h;

Reference yield:

→ 5-methoxy-3-oxopentanic acid ethyl ester (104629-86-9)

Guidance literature:

C2H5ONa, 1) /BRN= 102391/, CH3COOH, NaH (-2 bis 0gradC, unter N2), 2) LiC4H9/Hexan, 3) CH3OCH2Cl, /BRN= 102391/, 4) HCl;

upstream raw materials:

3-Methoxypropionitrile

ethyl bromoacetate

3-Methoxypropionic acid

ethyl potassium malonate

Downstream raw materials:

ethyl 2-[4-fluoro-3-(trifluoromethyl)benzyl]-5-methoxy-3-oxopentanoate

3-(2,6-dichloro-phenyl)-5-(2-methoxy-ethyl)-isoxazole-4-carboxylic acid ethyl ester

3-(2,6-dichloro-phenyl)-5-(2-methoxy-ethyl)-isoxazole-4-carboxylic acid