di-tert-butyl rac-(2R,3R)-2-methyl-3-phenylpentanedioate

Base Information

Chemical Name:di-tert-butyl rac-(2R,3R)-2-methyl-3-phenylpentanedioate
CAS No.:143585-06-2
Molecular Formula:C₂₀H₃₀O₄
Molecular Weight:334.456
Hs Code.:

Synonyms:

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Chemical Property of di-tert-butyl rac-(2R,3R)-2-methyl-3-phenylpentanedioate

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Technology Process of di-tert-butyl rac-(2R,3R)-2-methyl-3-phenylpentanedioate

There total 7 articles about di-tert-butyl rac-(2R,3R)-2-methyl-3-phenylpentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 20487-40-5
tert-butyl propionate

: 14990-09-1
tert-butyl cinnamate

: 143585-06-2,143585-17-5
rac-di-tert-butyl (2R,3S)-2-methyl-3-phenylpentanedioate

Guidance literature:: tert-butyl propionate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h; Inert atmosphere;

tert-butyl cinnamate; In tetrahydrofuran; hexane; at -78 ℃; for 1h; diastereospecific reaction; Inert atmosphere;
DOI:10.1016/j.tet.2019.130680

Reference yield: 85.0%

: 20487-40-5
tert-butyl propionate

: 14990-09-1
tert-butyl cinnamate

: 143585-06-2,143585-17-5
rac-di-tert-butyl (2R,3S)-2-methyl-3-phenylpentanedioate

Guidance literature:: tert-butyl propionate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h; Inert atmosphere;

tert-butyl cinnamate; In tetrahydrofuran; hexan-1-ol; at -78 ℃; for 1.41667h; Inert atmosphere;
DOI:10.1021/jacs.8b07776

Reference yield: 68.0%

: 20487-40-5
tert-butyl propionate

: 143585-06-2,143585-17-5
rac-di-tert-butyl (2R,3S)-2-methyl-3-phenylpentanedioate

: 143585-06-2,143585-17-5
di-tert-butyl rac-(2R,3R)-2-methyl-3-phenylpentanedioate

Guidance literature:: tert-butyl propionate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h; Inert atmosphere;

With titanium(IV) isopropylate; In tetrahydrofuran; hexane; at -78 - -40 ℃; Inert atmosphere;

rac-di-tert-butyl (2R,3S)-2-methyl-3-phenylpentanedioate; In tetrahydrofuran; hexane; at -40 ℃; for 0.5h; diastereospecific reaction; Inert atmosphere;
DOI:10.1016/j.tet.2019.130680