Telomerase inhibitors
Telomerase inhibitors are compounds that target and inhibit the activity of telomerase, an enzyme responsible for maintaining the length of telomeres, which are protective caps at the ends of chromosomes. Telomeres shorten with each cell division, and telomerase helps replenish and maintain their length, allowing cells to continue dividing indefinitely—a hallmark of cancer cells. Inhibiting telomerase can lead to telomere shortening and eventually cell senescence or death, making it a promising strategy for cancer therapy. Various approaches to inhibiting telomerase include small molecule inhibitors that disrupt telomerase activity or interfere with its assembly, as well as antisense oligonucleotides that target telomerase RNA components.
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![2-[[(2E)-3-(2-NAPHTHALENYL)-1-OXO-2-BUTEN-1-YL]AMINO]BENZOIC ACID](http://file1.lookchem.com/300w/2010-7/6355df84-d491-4213-81eb-2c7e434ff140.png)