Technology Process of (3R,5R,6R)-3-(2-Benzyloxy-ethyl)-6-methyl-7-trityloxy-heptane-1,5-diol
There total 13 articles about (3R,5R,6R)-3-(2-Benzyloxy-ethyl)-6-methyl-7-trityloxy-heptane-1,5-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 13 steps
1: H2O / acetone / PLE, pH 8.0
2: LiBH4
3: Ac2O, Py
6: LiAlH4
7: NaH
8: 1.) O3, 2.) Me2S
9: Et3N
10: 51 percent / KN(SiMe3)2, 18-crown-6
11: DIBAL
12: Py
13: 1.) thexylborane, 2.) NaOH, H2O2
With
pyridine; sodium hydroxide; lithium aluminium tetrahydride; lithium borohydride; 18-crown-6 ether; dimethylsulfide; thexylborane; water; dihydrogen peroxide; acetic anhydride; potassium hexamethylsilazane; sodium hydride; diisobutylaluminium hydride; ozone; triethylamine;
In
acetone;
- Guidance literature:
-
With
sodium hydroxide; thexylborane; dihydrogen peroxide;
Yield given. Multistep reaction;
- Guidance literature:
-
Multi-step reaction with 10 steps
3: LiAlH4
4: NaH
5: 1.) O3, 2.) Me2S
6: Et3N
7: 51 percent / KN(SiMe3)2, 18-crown-6
8: DIBAL
9: Py
10: 1.) thexylborane, 2.) NaOH, H2O2
With
pyridine; sodium hydroxide; lithium aluminium tetrahydride; 18-crown-6 ether; dimethylsulfide; thexylborane; dihydrogen peroxide; potassium hexamethylsilazane; sodium hydride; diisobutylaluminium hydride; ozone; triethylamine;
