1-BROMOMETHYL-2-CHLORO-4-METHOXYBENZENE

Base Information

• Chemical Name: 1-BROMOMETHYL-2-CHLORO-4-METHOXYBENZENE
• CAS No.: 54788-17-9
• Molecular Formula: C8H8BrClO
• Molecular Weight: 235.508
• Hs Code.: 2909309090
• Mol file: 54788-17-9.mol

Synonyms:1-BROMOMETHYL-2-CHLORO-4-METHOXYBENZENE;2-Chloro-4-methoxybenzyl bromide, 95%;Bromomethyl-2-Chloro-4-Methoxybenzene

Chemical Property of 1-BROMOMETHYL-2-CHLORO-4-METHOXYBENZENE

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Melting Point: 57-58°C
• Refractive Index: 1.565
• Boiling Point: 275.551 °C at 760 mmHg
• Flash Point: 120.449 °C
• PSA: 9.23000
• Density: 1.521 g/cm³
• LogP: 3.24350
• Storage Temp.: ?20°C

Purity/Quality:

97% ^*data from raw suppliers

1-Bromomethyl-2-chloro-4-methoxy-benzene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 34-25
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BROMOMETHYL-2-CHLORO-4-METHOXYBENZENE

There total 7 articles about 1-BROMOMETHYL-2-CHLORO-4-METHOXYBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-chloro-4-methoxy-1-methylbenzene (54788-38-4) → 2-chloro-4-methoxybenzyl bromide (54788-17-9)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 3h; Heating / reflux;

Reference yield:

(2-chloro-4-methoxyphenyl)methanol (334018-24-5) → 2-chloro-4-methoxybenzyl bromide (54788-17-9)

Guidance literature:

With hydrogen bromide; acetic acid;

DOI:10.1021/jm0512591

Reference yield:

3-monochlorophenol (108-43-0) → 2-chloro-4-methoxybenzyl bromide (54788-17-9)

Guidance literature:

Multi-step reaction with 4 steps

1: water; sodium carbonate; calcium hydroxide / 4.33 h / Inert atmosphere; Reflux

2: potassium carbonate / acetonitrile / 20 °C

3: sodium tetrahydroborate / ethanol / 2 h / 20 °C / Inert atmosphere

4: phosphorus tribromide / dichloromethane / 2 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; water; phosphorus tribromide; sodium carbonate; potassium carbonate; calcium hydroxide; In ethanol; dichloromethane; acetonitrile;

upstream raw materials:

2-chloro-4-methoxy-1-methylbenzene

(2-chloro-4-methoxyphenyl)methanol

3-monochlorophenol

2-chloro-4-hydroxybenzaldehyde

Downstream raw materials:

2-Chlor-4-methoxybenzyldiaethylphosphonat

2-[(E)-2-(2-chloro-4-methoxyphenyl)ethenyl]-5-methoxy-1H-indole

4-(2-chloro-4-methoxyphenyl)-9-methoxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

4-[4-(2-Chloro-4-methoxystyryl)-2-chlorobenzyl]heptane-3,5-dione