N1,1-Diphenylethane-1,2-diamine

Base Information

• Chemical Name: N1,1-Diphenylethane-1,2-diamine
• CAS No.: 42164-54-5
• Molecular Formula: C14H16N2
• Molecular Weight: 212.294
• Hs Code.: 2921590090
• DSSTox Substance ID: DTXSID50445043
• Nikkaji Number: J2.438.709G
• Mol file: 42164-54-5.mol

Synonyms:N1,1-Diphenylethane-1,2-diamine;42164-54-5;N,1-diphenylethane-1,2-diamine;N1,1-Diphenyl-1,2-ethanediamine;SCHEMBL7093029;DTXSID50445043;N-(2-amino-1-phenylethyl)aniline;AKOS014716942;SB78796

Chemical Property of N1,1-Diphenylethane-1,2-diamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.639
• Boiling Point: 368.3 °C at 760 mmHg
• PKA: 8.06±0.10(Predicted)
• Flash Point: 207.886 °C
• PSA: 38.05000
• Density: 1.114 g/cm³
• LogP: 3.57180
• Storage Temp.: 2-8°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 212.131348519
• Heavy Atom Count: 16
• Complexity: 181

Purity/Quality:

98%min ^*data from raw suppliers

N1,1-Diphenylethane-1,2-diamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CN)NC2=CC=CC=C2

Technology Process of N1,1-Diphenylethane-1,2-diamine

There total 10 articles about N1,1-Diphenylethane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

NSC 4573 (21080-09-1) → N-(2-amino-1-phenylethyl)benzenamine (42164-54-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.25h; Heating;

DOI:10.1016/S0040-4020(01)87547-5

Reference yield: 36.0%

2-anilino-2-phenylacetonitrile (4553-59-7) → N-Benzylaniline (758640-21-0,103-32-2) + N-(2-amino-1-phenylethyl)benzenamine (42164-54-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c4ra08048c

Reference yield:

2-anilino-2-phenylacetonitrile (4553-59-7) → N-(2-amino-1-phenylethyl)benzenamine (42164-54-5)

Guidance literature:

With acetic anhydride; platinum; Hydrogenation;

DOI:10.1021/jo01151a010

upstream raw materials:

2-anilino-2-phenylacetonitrile

NSC 4573

benzaldehyde

aniline

Downstream raw materials:

1,5-diphenylimidazolidin-2-one

C₄₃H₄₄N₄O₄S₂

N-{2-[4-(1,3-Dimethyl-2,4-dioxo-6-phenylamino-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide

N-{2-[4-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide

Refernces

• 1、 Gonzalez-Arellano, Camino,Yoshida, Kenta,Luque, Rafael,Gai, Pratibha L.. "Highly active and selective supported iron oxide nanoparticles in microwave-assisted N-alkylations of amines with alcohols". experimental part. p. 1281 - 1287. Retrieved 2010/10/04.
• 2、 Maillard, Michel C.,Perlman, Michael E.,Amitay, Oved,Baxter, Deborah,Berlove, David,Connaughton, Sonia,Fischer, James B.,Guo, Jun Qing,Hu, Lain-Yen,McBurney, Robert N.,Nagy, Peter I.,Subbarao, Katragadda,Yost, Elizabeth A.,Zhang, Lu,Durant, Graham J.. "Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels". . p. 3048 - 3061. Retrieved 2007/10/03.