N-{2-[4-(1,3-Dimethyl-2,4-dioxo-6-phenylamino-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-{2-[4-(1,3-Dimethyl-2,4-dioxo-6-phenylamino-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide
CAS No.:105159-28-2
Molecular Formula:C₃₄H₃₅N₅O₄S
Molecular Weight:609.749
Hs Code.:

N-{2-[4-(1,3-Dimethyl-2,4-dioxo-6-phenylamino-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide

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Chemical Property of N-{2-[4-(1,3-Dimethyl-2,4-dioxo-6-phenylamino-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide

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Technology Process of N-{2-[4-(1,3-Dimethyl-2,4-dioxo-6-phenylamino-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide

There total 5 articles about N-{2-[4-(1,3-Dimethyl-2,4-dioxo-6-phenylamino-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42164-54-5
N-(2-amino-1-phenylethyl)benzenamine

: 105159-28-2
N-{2-[4-(1,3-Dimethyl-2,4-dioxo-6-phenylamino-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 94 percent / ethanol; H₂O / 3 h / Heating

3: 6-anilino-1,3-dimethyluracil (1e), TFA / acetonitrile / Ambient temperature

With 6-anilino-1,3-dimethyluracil; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4020(01)87547-5

Reference yield:

: 21080-09-1
NSC 4573

: 105159-28-2
N-{2-[4-(1,3-Dimethyl-2,4-dioxo-6-phenylamino-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / Heating

2: 87 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 94 percent / ethanol; H₂O / 3 h / Heating

4: 6-anilino-1,3-dimethyluracil (1e), TFA / acetonitrile / Ambient temperature

With lithium aluminium tetrahydride; 6-anilino-1,3-dimethyluracil; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/S0040-4020(01)87547-5

Reference yield:

: 105159-32-8
4-methyl-N-(2-phenyl-2-(phenylamino)ethyl)benzenesulfonamide

: 105159-28-2
N-{2-[4-(1,3-Dimethyl-2,4-dioxo-6-phenylamino-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-phenylamino]-2-phenyl-ethyl}-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / ethanol; H₂O / 3 h / Heating

2: 6-anilino-1,3-dimethyluracil (1e), TFA / acetonitrile / Ambient temperature

With 6-anilino-1,3-dimethyluracil; trifluoroacetic acid; In ethanol; water; acetonitrile;
DOI:10.1016/S0040-4020(01)87547-5