2-(4-Methoxyphenyl)-tetrahydrofuran

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-tetrahydrofuran
• CAS No.: 79623-15-7
• Molecular Formula: C11H14O2
• Molecular Weight: 178.231
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID10402314
• Nikkaji Number: J1.165.179H
• Mol file: 79623-15-7.mol

Synonyms:2-(4-methoxyphenyl)-tetrahydrofuran;79623-15-7;2-(4-methoxyphenyl)oxolane;2-(4-Methoxyphenyl)tetrahydrofuran;4-(Oxolane-2-yl)anisole;DTXSID10402314;AKOS006372449;AM20041186;CS-0455851;FT-0685173;J-506051

Chemical Property of 2-(4-Methoxyphenyl)-tetrahydrofuran

Chemical Property:

• Melting Point: 61-63 °C
• Boiling Point: 140 °C(Press: 0.2 Torr)
• PSA: 18.46000
• Density: 1.061±0.06 g/cm3(Predicted)
• LogP: 2.54670
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 178.099379685
• Heavy Atom Count: 13
• Complexity: 150

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Methoxyphenyl)-tetrahydrofuran >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2CCCO2

Technology Process of 2-(4-Methoxyphenyl)-tetrahydrofuran

There total 30 articles about 2-(4-Methoxyphenyl)-tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.2%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + para-iodoanisole (696-62-8) → 2-p-methoxyphenyltetrahydrofuran (79623-15-7)

Guidance literature:

para-iodoanisole; With iodine; magnesium; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

tetrahydrofuran; With iron(III) oxide; at 0 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1039/c1cc11094b

Reference yield: 93.0%

1-(4’-methoxyphenyl)butan-1,4-diol (80174-16-9) → 2-p-methoxyphenyltetrahydrofuran (79623-15-7)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 25 ℃; for 0.25h; Product distribution; other 1,4-diols derived by reductive lithiation of var. oxetanes;

DOI:10.1021/jo00285a008

Reference yield: 93.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + 4-methoxyphenylboronic acid (5720-07-0) → 2-p-methoxyphenyltetrahydrofuran (79623-15-7)

Guidance literature:

tetrahydrofuran; 4-methoxyphenylboronic acid; With bis(acetylacetonate)nickel(II); potassium phosphate; triphenylphosphine; for 0.0833333h; Inert atmosphere; Schlenk technique;

With di-tert-butyl peroxide; at 100 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201300459

upstream raw materials:

homoalylic alcohol

(p-methoxyphenyl)tri-n-butylstannane

4-(4-methoxyphenyl)butan-1-ol

1-(4’-methoxyphenyl)butan-1,4-diol

Downstream raw materials:

(S)-2-(4’-methoxyphenyl)tetrahydrofuran