2-phenyl-2-(piperidin-1-yl)acetic acid

Base Information

• Chemical Name: 2-phenyl-2-(piperidin-1-yl)acetic acid
• CAS No.: 107416-49-9
• Molecular Formula: C13H17NO2
• Molecular Weight: 219.283
• Hs Code.: 2933399090
• Mol file: 107416-49-9.mol

Synonyms:phenyl-piperidino-acetic acid;Phenyl-piperidino-essigsaeure;2-phenyl-2-piperidylacetic acid;

Chemical Property of 2-phenyl-2-(piperidin-1-yl)acetic acid

Chemical Property:

• Melting Point: 197-201℃
• PSA: 40.54000
• LogP: 2.23610
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Phenyl-2-(piperidin-1-yl)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-phenyl-2-(piperidin-1-yl)acetic acid

There total 13 articles about 2-phenyl-2-(piperidin-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-phenyl-2-(piperidin-1-yl)acetate (23535-28-6) → phenyl(piperidin-1-yl)acetic acid (107416-49-9)

Guidance literature:

With hydrogenchloride;

Reference yield:

piperidine (110-89-4) → phenyl(piperidin-1-yl)acetic acid (107416-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyldiisopropylamine / acetonitrile / 4 h / 20 °C

2: NaOH / methanol; H₂O / 8 h / Heating

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; In methanol; water; acetonitrile;

DOI:10.1016/j.bmc.2006.02.028

Reference yield:

bromo-phenyl-acetic acid methyl ester (37167-62-7,3042-81-7,61139-20-6) → phenyl(piperidin-1-yl)acetic acid (107416-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyldiisopropylamine / acetonitrile / 4 h / 20 °C

2: NaOH / methanol; H₂O / 8 h / Heating

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; In methanol; water; acetonitrile;

DOI:10.1016/j.bmc.2006.02.028

upstream raw materials:

(R,S)-1-(1-piperidino)phenylacetamide

methyl 2-phenyl-2-(piperidin-1-yl)acetate

ethyl 2-phenyl-2-(piperidin-1-yl)acetate

Dipiproverin

Downstream raw materials:

Dipiproverin

AU₂₁₁₀₆

methyl-bis-[2-(phenyl-piperidino-acetoxy)-ethyl]-amine

methyl 2-phenyl-2-(piperidin-1-yl)acetate

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