Ethyl 2-phenyl-2-piperidinoacetate

Base Information

• Chemical Name: Ethyl 2-phenyl-2-piperidinoacetate
• CAS No.: 7550-06-3
• Molecular Formula: C15H21 N O2
• Molecular Weight: 247.337
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID80996957
• Nikkaji Number: J811.240A
• Mol file: 7550-06-3.mol

Synonyms:ethyl 2-phenyl-2-piperidinoacetate;7550-06-3;ethyl 2-phenyl-2-(piperidin-1-yl)acetate;ethyl 2-phenyl-2-piperidin-1-ylacetate;alpha-Phenyl-1-piperidineacetic acid ethyl ester;1-Piperidineacetic acid, alpha-phenyl-, ethyl ester;BRN 0206180;SCHEMBL2870098;DTXSID80996957;Ethyl phenyl(piperidin-1-yl)acetate;MFCD00445824;AKOS005070305;AT35997;ETHYL2-PHENYL-2-PIPERIDINOACETATE;phenyl-[2]piperidylacetic acid ethyl ester;LS-114143;FT-0680337;1-Piperidineacetic acid, -phenyl-, ethyl ester;Ethyl phenyl(1-piperidinyl)acetate, AldrichCPR;3X-0732;4-20-00-01079 (Beilstein Handbook Reference);J-520786;(alphaR)-alpha-Phenyl-1-piperidineacetic acid ethyl ester

Chemical Property of Ethyl 2-phenyl-2-piperidinoacetate

Chemical Property:

• Vapor Pressure: 0.000148mmHg at 25°C
• Boiling Point: 332.2°C at 760 mmHg
• Flash Point: 111°C
• PSA: 29.54000
• Density: 1.077g/cm³
• LogP: 2.71460
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 247.157228913
• Heavy Atom Count: 18
• Complexity: 255

Purity/Quality:

95% ^*data from raw suppliers

Ethyl2-Phenyl-2-piperidinoacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C1=CC=CC=C1)N2CCCCC2

Technology Process of Ethyl 2-phenyl-2-piperidinoacetate

There total 8 articles about Ethyl 2-phenyl-2-piperidinoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

piperidine (110-89-4) + ethyl 2-phenyl-2-bromoacetate (2882-19-1,2216-90-2) → ethyl 2-phenyl-2-(piperidin-1-yl)acetate (7550-06-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 1.5h;

Reference yield: 88.0%

piperidine (110-89-4) + glyoxylic acid ethyl ester (924-44-7) + bromobenzene (108-86-1,52753-63-6) → ethyl 2-phenyl-2-(piperidin-1-yl)acetate (7550-06-3)

Guidance literature:

bromobenzene; With cobalt(II) bromide; zinc; In acetonitrile; at 20 ℃; for 0.5h; Inert atmosphere;

piperidine; glyoxylic acid ethyl ester; In toluene; acetonitrile; at 25 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo1002328

Reference yield: 85.0%

piperidine (110-89-4) + ethyl 2-phenyldiazoacetate (22065-57-2) → ethyl 2-phenyl-2-(piperidin-1-yl)acetate (7550-06-3)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; In acetonitrile; for 7h; Reflux;

DOI:10.1021/ol800087p

upstream raw materials:

piperidine

ethyl 2-phenyl-2-bromoacetate

Benzotriazol-1-yl-piperidin-1-yl-acetic acid ethyl ester

ethyl 2-phenyldiazoacetate

Downstream raw materials:

Dipiproverin

phenyl-piperidino-acetic acid-(2-dimethylamino-ethyl ester)

1,1,2-triphenyl-2-piperidin-1-yl-ethanol

AU₂₁₁₀₆