n-Methylnifedipine

Base Information

Chemical Name:n-Methylnifedipine
CAS No.:30131-45-4
Molecular Formula:C₁₈H₂₀N₂O₆
Molecular Weight:360.367
Hs Code.:
DSSTox Substance ID:DTXSID301315966
Nikkaji Number:J438.070C

Synonyms:n-methylnifedipine;SCHEMBL1672208;CYCWGQFQPAYBHG-UHFFFAOYSA-N;DTXSID301315966;30131-45-4

Suppliers and Price of n-Methylnifedipine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of n-Methylnifedipine

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:360.13213636
Heavy Atom Count:26
Complexity:636

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1C)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC

Technology Process of n-Methylnifedipine

There total 4 articles about n-Methylnifedipine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 21829-25-4
nifedipine

: 74-88-4
methyl iodide

: 30131-45-4
dimethyl 1,2,6-trimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: nifedipine; methyl iodide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.166667h;

With potassium carbonate; In N,N-dimethyl-formamide; mineral oil; for 0.5h;
DOI:10.1002/anie.201210086

Reference yield: 8.0%

: 39562-27-1
methyl 2-(2'-nitrobenzylidene)acetoacetate

: 13412-12-9,21759-68-2,21759-69-3
3-methylaminobut-2-enoic acid methyl ester

: 30131-45-4
dimethyl 1,2,6-trimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: In acetonitrile; Heating;
DOI:10.1248/cpb.35.4819

Reference yield:

: 105-45-3
acetoacetic acid methyl ester

: 30131-45-4
dimethyl 1,2,6-trimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / H₂O / 18 h / Ambient temperature

2: 8 percent / acetonitrile / Heating

In water; acetonitrile;
DOI:10.1248/cpb.35.4819