2-{4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid diethyl ester

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Chemical Name:2-{4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid diethyl ester
CAS No.:123751-79-1
Molecular Formula:C₂₇H₃₄N₆O₅
Molecular Weight:522.604
Hs Code.:

Synonyms:

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Chemical Property of 2-{4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid diethyl ester

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Technology Process of 2-{4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid diethyl ester

There total 8 articles about 2-{4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 123751-73-5
4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoic acid

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 123751-79-1
2-{4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: With triethylamine; isobutyl chloroformate; In dimethyl sulfoxide; for 19.5h; Ambient temperature;
DOI:10.1021/jm00164a033

Reference yield:

: 2438-05-3
4-n-propylbenzoic acid

: 123751-79-1
2-{4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) LDA, HMPA / 1.) THF, hexane, a) 0-5 deg C, 6 h, b) RT temp., 22 h, 2.) 0-5 deg C

2: 28 percent / NaHCO₃ / dimethylformamide / 72 h / Ambient temperature

3: 97 percent / 1N HCl / acetic acid / 18 h / Ambient temperature

4: K₂CO₃ / 0.67 h / 60 °C

5: Et₃N / tetrahydrofuran / 1.) -20 deg C, 2.) RT, 15 h

6: 73 percent / conc. NH₄OH / methanol / 72 h / Ambient temperature

7: 1.) Na, 2.) H₂O / 1.) 2-methoxyethanol, 115-120 deg C, 24 h, 2.) 100 deg C, 4 h

8: 18 percent / Et₃N, isobutyl chloroformate / dimethylsulfoxide / 19.5 h / Ambient temperature

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium hydroxide; water; sodium; sodium hydrogencarbonate; potassium carbonate; triethylamine; lithium diisopropyl amide; isobutyl chloroformate; In tetrahydrofuran; methanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a033

Reference yield:

: 123751-66-6
4-(p-carbomethoxyphenyl)hexanal

: 123751-79-1
2-{4-[1-(2,4-Diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-propyl]-benzoylamino}-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / 0.67 h / 60 °C

2: Et₃N / tetrahydrofuran / 1.) -20 deg C, 2.) RT, 15 h

3: 73 percent / conc. NH₄OH / methanol / 72 h / Ambient temperature

4: 1.) Na, 2.) H₂O / 1.) 2-methoxyethanol, 115-120 deg C, 24 h, 2.) 100 deg C, 4 h

5: 18 percent / Et₃N, isobutyl chloroformate / dimethylsulfoxide / 19.5 h / Ambient temperature

With ammonium hydroxide; water; sodium; potassium carbonate; triethylamine; isobutyl chloroformate; In tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1021/jm00164a033