2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Base Information

• Chemical Name: 2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
• CAS No.: 1034297-69-2
• Molecular Formula: C12H18BNO3
• Molecular Weight: 235.091
• Hs Code.: 2934999090
• European Community (EC) Number: 680-907-1
• DSSTox Substance ID: DTXSID60590553
• Nikkaji Number: J2.687.036D
• Wikidata: Q72485745
• Mol file: 1034297-69-2.mol

Synonyms:1034297-69-2;2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;6-Methoxypyridine-2-boronic acid pinacol ester;MFCD06798266;2-methoxy-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine;SCHEMBL426945;(6-METHOXYPYRIDIN-2-YL)BORONIC ACID PINACOL ESTER;DTXSID60590553;VYWCRVNLPOVYJH-UHFFFAOYSA-N;2-METHOXY-6-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;AKOS015892237;Pyridine,2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;AB29906;AM84973;DS-13716;SY007669;DB-058992;CS-0041735;EN300-99723;2-Methoxypyridine-6-boronic acid pinacol ester;6-methoxy pyridine-2-boronic acid pinacol ester;6-METHOXYPYRIDINE-2-BORONICACIDPINACOLESTER;A800732;J-509837;Z1332365482;2-(Methyloxy)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;Azepino[4,5-b]indole-5-carboxylicacid,1,2,3,6-tetrahydro-1,1-dimethyl-,1-methylethylester

Chemical Property of 2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Chemical Property:

• Boiling Point: 329.056 °C at 760 mmHg
• PKA: 3.42±0.19(Predicted)
• Flash Point: 152.808 °C
• PSA: 40.58000
• Density: 1.067 g/cm³
• LogP: 1.38940
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Water Solubility.: Insoluble in water.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 235.1379736
• Heavy Atom Count: 17
• Complexity: 267

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B1(OC(C(O1)(C)C)(C)C)C2=NC(=CC=C2)OC
• Uses: It is used as an active pharmaceutical intermediate and also in the design, structure-activity relationship, and in vivo characterization of the development candidate nvp-hsp990.

Technology Process of 2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

There total 1 articles about 2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-2-methoxypyridine (40473-07-2) + bis(pinacol)diborane (73183-34-3) → 2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1034297-69-2)

Guidance literature:

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 80 ℃; for 2h;

Reference yield: 96.0%

2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1034297-69-2) + 2-chloro-4-phenoxypyrrolo[2,1-f][1,2,4]triazine → 2-(6-methoxypyridin-2-yl)-4-phenoxypyrrolo[2,1-f][1,2,4]triazine

Guidance literature:

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 100 ℃; for 12h; Inert atmosphere;

Reference yield: 92.0%

2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1034297-69-2) + methyl 5-bromopicolinate (29682-15-3) → methyl 6-methoxy-[2,3'-bipyridine]-6'-carboxylate

Guidance literature:

With caesium carbonate; In 1,4-dioxane; water; at 110 ℃; for 1.5h; Sealed tube; Microwave irradiation;

DOI:10.1016/j.ejmech.2016.11.044

upstream raw materials:

6-bromo-2-methoxypyridine

bis(pinacol)diborane

Downstream raw materials:

2-methoxy-6-phenylpyridine

2-methoxy-6-(4'-methoxyphenyl)pyridine

C₁₃H₁₃NO

C₁₃H₁₃NO