6-(4-Fluorophenyl)pyridine-3-boronic acid pinacol ester

Base Information

• Chemical Name: 6-(4-Fluorophenyl)pyridine-3-boronic acid pinacol ester
• CAS No.: 1073354-81-0
• Molecular Formula: C₁₇H₁₉BFNO₂
• Molecular Weight: 299.153
• Hs Code.: 2934999090
• Mol file: 1073354-81-0.mol

Synonyms:2-(4-FLUOROPHENYL)-5-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)PYRIDINE;

Chemical Property of 6-(4-Fluorophenyl)pyridine-3-boronic acid pinacol ester

Chemical Property:

• Vapor Pressure: 2.53E-06mmHg at 25°C
• Boiling Point: 402.5°C at 760 mmHg
• Flash Point: 197.2°C
• PSA: 31.35000
• Density: 1.14g/cm³
• LogP: 3.18690

Purity/Quality:

97% ^*data from raw suppliers

6-(4-Fluorophenyl)pyridine-3-boronic acid pinacol ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Used in organic synthesis. The boronic esters are widely used for carrying out cross coupling reactions.

Technology Process of 6-(4-Fluorophenyl)pyridine-3-boronic acid pinacol ester

There total 5 articles about 6-(4-Fluorophenyl)pyridine-3-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H7ClFN (1214327-65-7) + bis(pinacol)diborane (73183-34-3) → C17H19BFNO2 (1073354-81-0)

Guidance literature:

With potassium acetate; XPhos; In 1,4-dioxane; at 80 ℃; for 24h;

DOI:10.1016/j.bmcl.2011.10.037

Reference yield:

2,5 dichloropyridine (16110-09-1) → C17H19BFNO2 (1073354-81-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 24 h / 80 °C

2: potassium acetate; XPhos / 1,4-dioxane / 24 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; XPhos; In 1,4-dioxane; ethanol; water; toluene; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.10.037

Reference yield:

4-fluoroboronic acid (1765-93-1) → C17H19BFNO2 (1073354-81-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 24 h / 80 °C

2: potassium acetate; XPhos / 1,4-dioxane / 24 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; XPhos; In 1,4-dioxane; ethanol; water; toluene; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.10.037

upstream raw materials:

2,5 dichloropyridine

C₁₁H₇ClFN

bis(pinacol)diborane

4-fluoroboronic acid

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