4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE

Base Information

• Chemical Name: 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE
• CAS No.: 364334-94-1
• Molecular Formula: C9H10N4S
• Molecular Weight: 206.2675
• Hs Code.: 2934100090
• Mol file: 364334-94-1.mol

Synonyms:4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE;4-(diMethyl-1,3-thiazol-5-yl)pyriMidin-2-aMine

Chemical Property of 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE

Chemical Property:

• PSA: 92.93000
• LogP: 2.38030
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-(2,4-Dimethyl-thiazol-5-yl)pyrimidin-2-ylamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE

There total 3 articles about 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

guanidine hydrogen carbonate (124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9) + (E)-3-(dimethylamino)-1-(2,4-dimethylthiazol-5-yl)prop-2-en-1-one → 4-(2,4-dimethylthiazol-5-yl)pyrimidin-2-ylamine (364334-94-1)

Guidance literature:

With sodium hydroxide; In 2-methoxy-ethanol; at 125 ℃; for 22h;

DOI:10.1021/jm0309957

Reference yield:

guanidine nitrate (113-00-8) + (E)-3-(dimethylamino)-1-(2,4-dimethylthiazol-5-yl)prop-2-en-1-one → 4-(2,4-dimethylthiazol-5-yl)pyrimidin-2-ylamine (364334-94-1)

Guidance literature:

In 2-methoxethanol;

Reference yield:

5-acetyl-2,4-dimethylthiazole (38205-60-6) → 4-(2,4-dimethylthiazol-5-yl)pyrimidin-2-ylamine (364334-94-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / 21 h / Heating

2: 33 percent / NaOH / 2-methoxy-ethanol / 22 h / 125 °C

With sodium hydroxide; In 2-methoxy-ethanol;

DOI:10.1021/jm0309957

upstream raw materials:

guanidine hydrogen carbonate

5-acetyl-2,4-dimethylthiazole

guanidine nitrate

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