8-(4-Methanesulfonyl-benzenesulfonylamino)-4-(3-pyridin-3-yl-propyl)-octanoic acid methyl ester

Base Information

• Chemical Name: 8-(4-Methanesulfonyl-benzenesulfonylamino)-4-(3-pyridin-3-yl-propyl)-octanoic acid methyl ester
• CAS No.: 1026605-63-9
• Molecular Formula: C₂₄H₃₄N₂O₆S₂
• Molecular Weight: 510.676
• Mol file: 1026605-63-9.mol

Synonyms:

Chemical Property of 8-(4-Methanesulfonyl-benzenesulfonylamino)-4-(3-pyridin-3-yl-propyl)-octanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(4-Methanesulfonyl-benzenesulfonylamino)-4-(3-pyridin-3-yl-propyl)-octanoic acid methyl ester

There total 10 articles about 8-(4-Methanesulfonyl-benzenesulfonylamino)-4-(3-pyridin-3-yl-propyl)-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(pyridin-3-yl)propyl bromide hydrobromide (41038-63-5) → 8-(4-Methanesulfonyl-benzenesulfonylamino)-4-(3-pyridin-3-yl-propyl)-octanoic acid methyl ester (1026605-63-9)

Guidance literature:

Multi-step reaction with 10 steps

1: 1.) Na / 1.) EtOH, 2.) EtOH, reflux, 10 h

2: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, 60 deg C, 10 h

3: NaN₃, NaI, 18-crown-6 / dimethylformamide / 18 h / 60 °C

4: Ph₃P, H₂O / tetrahydrofuran / 62 h / Ambient temperature

5: 6N HCl / acetic acid / 18 h / Heating

6: SOCl₂ / 18 h / Heating

7: Et₃N / CH₂Cl₂ / 18 h

8: diisobutylaluminum hydride / CH₂Cl₂; toluene / 0.08 h / -78 °C

9: CHCl₃ / 18 h

10: NaBH₄, CoCl₂*6H₂O / 1 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; sodium azide; 18-crown-6 ether; water; sodium; sodium hydride; diisobutylaluminium hydride; triethylamine; triphenylphosphine; sodium iodide; cobalt(II) chloride; In tetrahydrofuran; dichloromethane; chloroform; acetic acid; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00101a015

Reference yield:

6-Amino-2-(3-pyridin-3-yl-propyl)-hexanoic acid (144385-78-4) → 8-(4-Methanesulfonyl-benzenesulfonylamino)-4-(3-pyridin-3-yl-propyl)-octanoic acid methyl ester (1026605-63-9)

Guidance literature:

Multi-step reaction with 5 steps

1: SOCl₂ / 18 h / Heating

2: Et₃N / CH₂Cl₂ / 18 h

3: diisobutylaluminum hydride / CH₂Cl₂; toluene / 0.08 h / -78 °C

4: CHCl₃ / 18 h

5: NaBH₄, CoCl₂*6H₂O / 1 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; diisobutylaluminium hydride; triethylamine; cobalt(II) chloride; In dichloromethane; chloroform; toluene;

DOI:10.1021/jm00101a015

Reference yield:

ethyl 6-amino-2-<(3-pyridinyl)propyl>hexanoate (144385-62-6) → 8-(4-Methanesulfonyl-benzenesulfonylamino)-4-(3-pyridin-3-yl-propyl)-octanoic acid methyl ester (1026605-63-9)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 18 h

2: diisobutylaluminum hydride / CH₂Cl₂; toluene / 0.08 h / -78 °C

3: CHCl₃ / 18 h

4: NaBH₄, CoCl₂*6H₂O / 1 h / Ambient temperature

With sodium tetrahydroborate; diisobutylaluminium hydride; triethylamine; cobalt(II) chloride; In dichloromethane; chloroform; toluene;

DOI:10.1021/jm00101a015

upstream raw materials:

3-(pyridin-3-yl)propyl bromide hydrobromide

6-Amino-2-(3-pyridin-3-yl-propyl)-hexanoic acid

ethyl 6-amino-2-<(3-pyridinyl)propyl>hexanoate

diethyl [3-(pyridin-3-yl)-propyl]-malonate

Refernces