6-chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride

Base Information

• Chemical Name: 6-chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride
• CAS No.: 928324-59-8
• Molecular Formula: C6H2Cl2F3NO2S
• Molecular Weight: 280.05
• Hs Code.: 2933399090
• Mol file: 928324-59-8.mol

Synonyms:6-chloro-5-(trifluoromethyl)-3-Pyridinesulfonyl chloride;6-chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride

Chemical Property of 6-chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride

Chemical Property:

• PSA: 55.41000
• LogP: 3.76210
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride

There total 4 articles about 6-chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

6-chloro-5-(trifluoromethyl)pyridin-3-amine (99368-68-0) → 6-chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride (928324-59-8)

Guidance literature:

6-chloro-5-(trifluoromethyl)pyridin-3-amine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.166667h;

With sulfur dioxide; copper(l) chloride; In water; at 5 ℃; for 0.5h;

Reference yield:

2-chloro-5-nitro-3-(trifluoromethyl)pyridine (99368-67-9) → 6-chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride (928324-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; ammonium chloride / methanol; water / 4 h / 20 °C

2: hydrogenchloride; sulfur dioxide; sodium nitrite; thionyl chloride / 1,4-dioxane / 0 °C

With hydrogenchloride; thionyl chloride; sulfur dioxide; iron; ammonium chloride; sodium nitrite; In 1,4-dioxane; methanol; water;

Reference yield:

2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine (887707-23-5) → 6-chloro-5-(trifluoromethyl)pyridine-3-sulfonyl chloride (928324-59-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 5 h / 0 - 50 °C

2: trichlorophosphate; phosphorus pentachloride / 3 h / 90 °C

3: iron; ammonium chloride / methanol; water / 4 h / 20 °C

4: hydrogenchloride; sulfur dioxide; sodium nitrite; thionyl chloride / 1,4-dioxane / 0 °C

With hydrogenchloride; thionyl chloride; phosphorus pentachloride; sulfuric acid; sulfur dioxide; nitric acid; iron; ammonium chloride; sodium nitrite; trichlorophosphate; In 1,4-dioxane; methanol; water;

upstream raw materials:

6-chloro-5-(trifluoromethyl)pyridin-3-amine

2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine

2-hydroxyl-5-nitro-3-(trifluoromethyl)pyridine

2-chloro-5-nitro-3-(trifluoromethyl)pyridine

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