FGFR-IN-1

Base Information

• Chemical Name: FGFR-IN-1
• CAS No.: 1448169-71-8
• Molecular Formula: C₂₂H₂₂N₆O₃
• Molecular Weight: 418.455
• Mol file: 1448169-71-8.mol

Synonyms:

Chemical Property of FGFR-IN-1

Chemical Property:

• Boiling Point: 733.8±60.0 °C(Predicted)
• PKA: 3.60±0.30(Predicted)
• Density: 1.33±0.1 g/cm3(Predicted)

Purity/Quality:

99%+, ^*data from raw suppliers

TAS-120 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Futibatinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. Futibatinib selectively and irreversibly binds to and inhibits FGFR, which may result in the inhibition of both the FGFR-mediated signal transduction pathway and tumor cell proliferation, and increased cell death in FGFR-overexpressing tumor cells. FGFR is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival and its expression is upregulated in many tumor cell types.

Technology Process of FGFR-IN-1

There total 16 articles about FGFR-IN-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

(S)-3-((3,5-dimethoxyphenyl)ethynyl)-1-(pyrrolidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine dimethanesulphonate + 2-chloropropionyl chloride (625-36-5) → 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one (1448169-71-8)

Guidance literature:

With sodium hydroxide; In water; acetonitrile; at 30 ℃; for 4.66667h; Reagent/catalyst; Temperature;

Reference yield: 85.3%

2-chloropropionyl chloride (625-36-5) → 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one (1448169-71-8)

Guidance literature:

Reference yield: 78.2%

(S)-3-((3,5-dimethoxyphenyl)ethynyl)-1-(pyrrolidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine dimethanesulphonate + acryloyl chloride (814-68-6,25189-84-8) → 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one (1448169-71-8)

Guidance literature:

(S)-3-((3,5-dimethoxyphenyl)ethynyl)-1-(pyrrolidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine dimethanesulphonate; acryloyl chloride; With potassium phosphate; In water; at 10 ℃; for 3h;

With phosphoric acid; In water; at 20 - 30 ℃; for 3h; Reagent/catalyst; Temperature; Solvent;

upstream raw materials:

2-chloropropionyl chloride

1-methyl-pyrrolidin-2-one

acryloyl chloride

1-Ethynyl-3,5-dimethoxy-benzene

Refernces

• 1、 -. "THERAPEUTIC AGENT FOR FGFR INHIBITOR-RESISTANT CANCER". Paragraph 0286; 0289. . Retrieved 2016/06/06.
• 2、 -. "3,5-DISUBSTITUTED ALKYNYLBENZENE COMPOUND AND SALT THEREOF". Paragraph 0195; 0198. . Retrieved 2013/11/19.