(R)-5-(4-chlorophenyl)-4-(3-(4-(4-(((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)phenyl)sulfonyl)carbamoyl)phenyl)piperazin-1-yl)phenyl)-1,2-dimethyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrole-3-carboxamide

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Chemical Name:(R)-5-(4-chlorophenyl)-4-(3-(4-(4-(((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)phenyl)sulfonyl)carbamoyl)phenyl)piperazin-1-yl)phenyl)-1,2-dimethyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrole-3-carboxamide
CAS No.:1384512-95-1
Molecular Formula:C₅₆H₆₇ClN₁₀O₆S₂
Molecular Weight:1075.8
Hs Code.:

(R)-5-(4-chlorophenyl)-4-(3-(4-(4-(((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)phenyl)sulfonyl)carbamoyl)phenyl)piperazin-1-yl)phenyl)-1,2-dimethyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrole-3-carboxamide

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Chemical Property of (R)-5-(4-chlorophenyl)-4-(3-(4-(4-(((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)phenyl)sulfonyl)carbamoyl)phenyl)piperazin-1-yl)phenyl)-1,2-dimethyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrole-3-carboxamide

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Technology Process of (R)-5-(4-chlorophenyl)-4-(3-(4-(4-(((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)phenyl)sulfonyl)carbamoyl)phenyl)piperazin-1-yl)phenyl)-1,2-dimethyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrole-3-carboxamide

There total 5 articles about (R)-5-(4-chlorophenyl)-4-(3-(4-(4-(((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)phenyl)sulfonyl)carbamoyl)phenyl)piperazin-1-yl)phenyl)-1,2-dimethyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1384513-05-6
ethyl 2-acetyl-4-(4-chlorophenyl)-3-(3-iodophenyl)-4-oxobutanoate

: 1384512-95-1
(R)-5-(4-chlorophenyl)-4-(3-(4-(4-(((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)phenyl)sulfonyl)carbamoyl)phenyl)piperazin-1-yl)phenyl)-1,2-dimethyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / Inert atmosphere

2: sodium hydroxide / 1,4-dioxane; ethanol; water / Reflux; Inert atmosphere

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / Inert atmosphere

4: tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate / N,N-dimethyl-formamide; toluene / 20 - 70 °C / Inert atmosphere

With tri-tert-butyl phosphine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Paal-Knorr pyrrole synthesis / 4: Buchwald-Hartwig reaction;
DOI:10.1021/jm300608w

Reference yield:

: ethyl 2-(3-iodobenzylidene)-3-oxobutanoate

: 1384512-95-1
(R)-5-(4-chlorophenyl)-4-(3-(4-(4-(((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)phenyl)sulfonyl)carbamoyl)phenyl)piperazin-1-yl)phenyl)-1,2-dimethyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / 70 °C / Inert atmosphere

2: methanol / Inert atmosphere

3: sodium hydroxide / 1,4-dioxane; ethanol; water / Reflux; Inert atmosphere

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / Inert atmosphere

5: tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate / N,N-dimethyl-formamide; toluene / 20 - 70 °C / Inert atmosphere

With tri-tert-butyl phosphine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2: Paal-Knorr pyrrole synthesis / 5: Buchwald-Hartwig reaction;
DOI:10.1021/jm300608w

Reference yield:

: 696-41-3
m-iodobenzaldehyde

: 1384512-95-1
(R)-5-(4-chlorophenyl)-4-(3-(4-(4-(((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)phenyl)sulfonyl)carbamoyl)phenyl)piperazin-1-yl)phenyl)-1,2-dimethyl-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: piperidine; acetic acid / toluene / Inert atmosphere; Reflux

2: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / 70 °C / Inert atmosphere

3: acetic acid / methanol / 24 h / 65 °C / Inert atmosphere; Sealed tube

4: sodium hydroxide / 1,4-dioxane; ethanol; water / Reflux; Inert atmosphere

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 8 h / Inert atmosphere

6: tri-tert-butyl phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate / N,N-dimethyl-formamide; toluene / 20 - 70 °C / Inert atmosphere

With piperidine; tri-tert-butyl phosphine; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3: Paal-Knorr pyrrole synthesis / 6: Buchwald-Hartwig reaction;
DOI:10.1021/jm300608w