(R)-1-(3-Pyridyl)ethanol

Base Information

• Chemical Name: (R)-1-(3-Pyridyl)ethanol
• CAS No.: 7606-26-0
• Molecular Formula: C₇H₈NO*H
• Molecular Weight: 123.155
• Hs Code.: 2933399990
• European Community (EC) Number: 845-276-0
• DSSTox Substance ID: DTXSID50444915
• Nikkaji Number: J64.124C
• Wikidata: Q82263193
• Mol file: 7606-26-0.mol

Synonyms:(R)-1-(3-PYRIDYL)ETHANOL;7606-26-0;(R)-1-(PYRIDIN-3-YL)ETHANOL;(1R)-1-pyridin-3-ylethanol;(1R)-1-(3-Pyridyl)ethanol;(1R)-1-(pyridin-3-yl)ethan-1-ol;(R)-3-(1-HYDROXYETHYL)PYRIDINE;MFCD07368883;(R)-1-(pyridin-3-yl)ethan-1-ol;r-(3-pyridyl)ethanol;SCHEMBL4098469;DTXSID50444915;QMDUEBURHKSKDG-ZCFIWIBFSA-N;(+)-(R)-1-(3-pyridyl)ethanol;AMY19998;AKOS010401401;(alphaR)-alpha-Methyl-3-pyridinemethanol;CS-11177;(R)-(+)-alpha-methyl-3-pyridinemethanol;CS-0093784;EN300-52665;A838601;(1R)-1-(3-pyridyl)ethanol;(R)-1-(3-Pyridyl)ethanol;Z360055290

Chemical Property of (R)-1-(3-Pyridyl)ethanol

Chemical Property:

• Vapor Pressure: 0.022mmHg at 25°C
• Refractive Index: 1.535
• Boiling Point: 239.602 °C at 760 mmHg
• PKA: 13.75±0.20(Predicted)
• Flash Point: 98.708 °C
• PSA: 33.12000
• Density: 1.083 g/cm³
• LogP: 1.13490
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-(3-Pyridyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CN=CC=C1)O
• Isomeric SMILES: C[C@H](C1=CN=CC=C1)O

Technology Process of (R)-1-(3-Pyridyl)ethanol

There total 18 articles about (R)-1-(3-Pyridyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R)-1-(3-pyridyl)ethyl acetate (27854-86-0) → (R)-1-(3-pyridyl)ethanol (5096-11-7,10593-35-8,4754-27-2,7606-26-0)

Guidance literature:

With sodium hydroxide; In methanol; for 12h; Ambient temperature;

DOI:10.3987/R-1987-12-3051

Reference yield: 99.1%

methyl-3-pyridylketone (350-03-8) → (R)-1-(3-pyridyl)ethanol (5096-11-7,10593-35-8,4754-27-2,7606-26-0)

Guidance literature:

With C₅₀H₆₈FeN₄P₂⁽²⁺⁾*2BF₄^(1-); sodium t-butanolate; In isopropyl alcohol; at 50 ℃; for 1h; Reagent/catalyst; Temperature; enantioselective reaction; Glovebox; Schlenk technique;

DOI:10.1002/anie.201501807

Reference yield: 53.0%

1-(3-Pyridyl)ethyl acetate (35692-86-5) → (S)-3-(1-hydroxyethyl)pyridine (5096-11-7) + (R)-1-(3-pyridyl)ethanol (5096-11-7,10593-35-8,4754-27-2,7606-26-0)

Guidance literature:

With Rhizopus nigricans (sterile potato dextrose medium); In tetrahydrofuran; for 16h; Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00166a016

upstream raw materials:

methyl-3-pyridylketone

1-(3-Pyridyl)ethanol

1-(3-Pyridyl)ethyl acetate

(1R)-1-(3-pyridyl)ethyl acetate

Downstream raw materials:

(1R)-1-(1-benzyl-1,2,5,6-tetrahydro-3-pyridyl)ethanol

(R)-3-Eth-(Z)-ylidene-4-(1H-indol-2-ylmethyl)-piperidine-1-carboxylic acid benzyl ester

(R,Z)-benzyl 3-ethylidene-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate

5-((R)-1-Hydroxy-ethyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester