Technology Process of 3-(2-{[(tert-butyldimethylsilyl)oxy][2H2]methyl}phenyl)-10-(4-tert-butylphenyl)[5-2H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione
There total 13 articles about 3-(2-{[(tert-butyldimethylsilyl)oxy][2H2]methyl}phenyl)-10-(4-tert-butylphenyl)[5-2H]pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: LiAlD4 / diethyl ether
2: pyridinium chlorochromate / CH2Cl2
3: dimethylformamide / 6 h / 100 °C
4: H2SO4 / H2O / 5 h / 130 °C
5: NaBD4, BF3*Et2O / tetrahydrofuran / 1 h / Ambient temperature
6: DDQ / CHCl3 / 0.25 h / Ambient temperature
7: imidazole / dimethylformamide / 1 h / Ambient temperature
With
1H-imidazole; lithium aluminium deuteride; sodium borodeuteride; sulfuric acid; boron trifluoride diethyl etherate; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; diethyl ether; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jo961799t
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 76 percent / butan-1-ol / 3 h / Heating
2: dimethylformamide / 6 h / 100 °C
3: H2SO4 / H2O / 5 h / 130 °C
4: NaBD4, BF3*Et2O / tetrahydrofuran / 1 h / Ambient temperature
5: DDQ / CHCl3 / 0.25 h / Ambient temperature
6: imidazole / dimethylformamide / 1 h / Ambient temperature
With
1H-imidazole; sodium borodeuteride; sulfuric acid; boron trifluoride diethyl etherate; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/jo961799t
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 90 percent / NaOMe / methanol / 16 h / Heating
2: 72 percent / POCl3 / H2O / 28 h / 60 °C
3: 76 percent / butan-1-ol / 3 h / Heating
4: dimethylformamide / 6 h / 100 °C
5: H2SO4 / H2O / 5 h / 130 °C
6: NaBD4, BF3*Et2O / tetrahydrofuran / 1 h / Ambient temperature
7: DDQ / CHCl3 / 0.25 h / Ambient temperature
8: imidazole / dimethylformamide / 1 h / Ambient temperature
With
1H-imidazole; sodium borodeuteride; sulfuric acid; boron trifluoride diethyl etherate; sodium methylate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; trichlorophosphate;
In
tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/jo961799t
