N-[2-{3-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-3-oxo-propionyl}-4-methyl-3-(tetrahydro-pyran-2-yloxy)-phenyl]-2,2-dimethyl-propionamide

Base Information

Chemical Name:N-[2-{3-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-3-oxo-propionyl}-4-methyl-3-(tetrahydro-pyran-2-yloxy)-phenyl]-2,2-dimethyl-propionamide
CAS No.:1026462-88-3
Molecular Formula:C₃₁H₃₉FN₂O₆
Molecular Weight:554.659
Hs Code.:

N-[2-{3-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-3-oxo-propionyl}-4-methyl-3-(tetrahydro-pyran-2-yloxy)-phenyl]-2,2-dimethyl-propionamide

Synonyms:

Suppliers and Price of N-[2-{3-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-3-oxo-propionyl}-4-methyl-3-(tetrahydro-pyran-2-yloxy)-phenyl]-2,2-dimethyl-propionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[2-{3-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-3-oxo-propionyl}-4-methyl-3-(tetrahydro-pyran-2-yloxy)-phenyl]-2,2-dimethyl-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[2-{3-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-3-oxo-propionyl}-4-methyl-3-(tetrahydro-pyran-2-yloxy)-phenyl]-2,2-dimethyl-propionamide

There total 3 articles about N-[2-{3-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-3-oxo-propionyl}-4-methyl-3-(tetrahydro-pyran-2-yloxy)-phenyl]-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 367-24-8
4-bromo-2-fluoroaniline

: 1026462-88-3
N-[2-{3-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-3-oxo-propionyl}-4-methyl-3-(tetrahydro-pyran-2-yloxy)-phenyl]-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / pyridine / Ambient temperature

2: 66 percent / n-BuLi / tetrahydrofuran / -78 °C

3: NaH / dioxane; toluene / 2 h / Heating

With pyridine; n-butyllithium; sodium hydride; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1021/jm9700326

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1026462-88-3
N-[2-{3-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-3-oxo-propionyl}-4-methyl-3-(tetrahydro-pyran-2-yloxy)-phenyl]-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / pyridine / Ambient temperature

2: 66 percent / n-BuLi / tetrahydrofuran / -78 °C

3: NaH / dioxane; toluene / 2 h / Heating

With pyridine; n-butyllithium; sodium hydride; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1021/jm9700326

Reference yield:

: 165180-44-9
N-(4-bromo-2-fluorophenyl)pivalamide

: 1026462-88-3
N-[2-{3-[4-(2,2-Dimethyl-propionylamino)-3-fluoro-phenyl]-3-oxo-propionyl}-4-methyl-3-(tetrahydro-pyran-2-yloxy)-phenyl]-2,2-dimethyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / n-BuLi / tetrahydrofuran / -78 °C

2: NaH / dioxane; toluene / 2 h / Heating

With n-butyllithium; sodium hydride; In tetrahydrofuran; 1,4-dioxane; toluene;
DOI:10.1021/jm9700326