(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosine ester

Base Information

Chemical Name:(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosine ester
CAS No.:196950-26-2
Molecular Formula:C₂₆H₃₈N₄O₉
Molecular Weight:550.609
Hs Code.:

Synonyms:(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosine ester

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Chemical Property of (2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosine ester

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Technology Process of (2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosine ester

There total 8 articles about (2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosine ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 196950-24-0
Benzyl (2S)-N-(tert-butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosinate diester

: 196950-26-2
(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosine ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 12h;
DOI:10.1039/a702410j

Reference yield:

: 118700-84-8
(S)-3-(2-(tert-butoxycarbonylamino)-3-phenyl-propanamido)propanoic acid

: 196950-26-2
(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosine ester

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

3: 91 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 21 h

4: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

5: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

6: 95 percent / H₂ / 5percent Pd/C / methanol / 12 h

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1039/a702410j

Reference yield:

: 110473-10-4
N-Boc-D-Glu α-methyl ester

: 196950-26-2
(2S)-N-(tert-Butoxycarbonyl)phenylalanyl-β-alanyl-(α-methyl (2R)-glutamyl)-γ-sarcosine ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / HCl / ethyl acetate / 1 h / 0 °C

2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

3: 91 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 21 h

4: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

5: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

6: 95 percent / H₂ / 5percent Pd/C / methanol / 12 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; ethyl acetate;
DOI:10.1039/a702410j