1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid

Base Information

• Chemical Name: 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid
• CAS No.: 17288-35-6
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.148
• Hs Code.: 2933990090
• Mol file: 17288-35-6.mol

Synonyms:4-Azaindole-2-carboxylic acid;

Chemical Property of 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 9.1E-09mmHg at 25°C
• Refractive Index: 1.743
• Boiling Point: 446.8 °C at 760 mmHg
• Flash Point: 224 °C
• PSA: 65.98000
• Density: 1.506 g/cm³
• LogP: 1.26110
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1H-?Pyrrolo[3,?2-?b]?pyridine-?2-?carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1H-?Pyrrolo[3,?2-?b]?pyridine-?2-?carboxylic Acid is a useful organic reagent for synthesis of substituted 4- and 6-azaindoles and indolecarboxamides as H4 receptor ligands.

Technology Process of 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid

There total 11 articles about 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester (17288-32-3) → 1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid (17288-35-6)

Guidance literature:

1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester; With lithium hydroxide; In ethanol; water; for 16h;

In ethanol; water; pH=4; Acidic conditions;

DOI:10.1016/j.ejmech.2012.06.016

Reference yield: 64.0%

1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester (17288-32-3) → 1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid amide (853685-35-5) + 1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid (17288-35-6)

Guidance literature:

With ammonia; water; at 60 ℃; for 5h; under 1034.32 Torr;

DOI:10.1021/op200171a

Reference yield:

3-amino-2-bromopyridine (39856-58-1) + 2-oxo-propionic acid (127-17-3) → 1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid (17288-35-6)

Guidance literature:

With triethylamine; triphenylphosphine; palladium diacetate; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 4h;

upstream raw materials:

3-amino-2-bromopyridine

2-oxo-propionic acid

1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester

methanol

Downstream raw materials:

1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester

methyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate