4-nitro-benzenesulfonic acid 2-[[3-(3-chloro-phenyl)-2-hydroxy-3-(2-methoxy-phenoxy)-propyl]-(4-nitro-benzenesulfonyl)-amino]-ethyl ester

Base Information

• Chemical Name: 4-nitro-benzenesulfonic acid 2-[[3-(3-chloro-phenyl)-2-hydroxy-3-(2-methoxy-phenoxy)-propyl]-(4-nitro-benzenesulfonyl)-amino]-ethyl ester
• CAS No.: 863969-86-2
• Molecular Formula: C₃₀H₂₈ClN₃O₁₂S₂
• Molecular Weight: 722.15
• Mol file: 863969-86-2.mol

Synonyms:

Chemical Property of 4-nitro-benzenesulfonic acid 2-[[3-(3-chloro-phenyl)-2-hydroxy-3-(2-methoxy-phenoxy)-propyl]-(4-nitro-benzenesulfonyl)-amino]-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitro-benzenesulfonic acid 2-[[3-(3-chloro-phenyl)-2-hydroxy-3-(2-methoxy-phenoxy)-propyl]-(4-nitro-benzenesulfonyl)-amino]-ethyl ester

There total 9 articles about 4-nitro-benzenesulfonic acid 2-[[3-(3-chloro-phenyl)-2-hydroxy-3-(2-methoxy-phenoxy)-propyl]-(4-nitro-benzenesulfonyl)-amino]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rac-(3-(3-chlorophenyl)oxiran-2-yl)methanol (125617-30-3) → 4-nitro-benzenesulfonic acid 2-[[3-(3-chloro-phenyl)-2-hydroxy-3-(2-methoxy-phenoxy)-propyl]-(4-nitro-benzenesulfonyl)-amino]-ethyl ester (863969-86-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: aq. NaOH; methyltributylammonium chloride / CH₂Cl₂ / 2 h / 20 °C

1.2: 39 percent / 3 h / 65 °C

2.1: Et₃N / ethyl acetate / 0.25 h / -20 °C

3.1: Et₃N / ethyl acetate / 0.25 h / -20 °C

4.1: aq. HCl / ethyl acetate / -20 - 20 °C

5.1: aq. NaOH; methyltributylammonium chloride / toluene / 20 °C

6.1: 48 percent / propan-2-ol / Heating

7.1: Et₃N / CH₂Cl₂

With hydrogenchloride; sodium hydroxide; triethylamine; methyl tributylammonium chloride; In dichloromethane; ethyl acetate; isopropyl alcohol; toluene;

DOI:10.1016/j.tetasy.2005.06.012

Reference yield:

1,2-epoxy-3-[(3-chlorophenyl)-(2-methoxyphenoxy)]propane (863969-83-9) → 4-nitro-benzenesulfonic acid 2-[[3-(3-chloro-phenyl)-2-hydroxy-3-(2-methoxy-phenoxy)-propyl]-(4-nitro-benzenesulfonyl)-amino]-ethyl ester (863969-86-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / propan-2-ol / Heating

2: Et₃N / CH₂Cl₂

With triethylamine; In dichloromethane; isopropyl alcohol;

DOI:10.1016/j.tetasy.2005.06.012

Reference yield:

3-(3-chlorophenyl)-3-(2-methoxyphenoxy)-propane-1,2-diol (863969-82-8) → 4-nitro-benzenesulfonic acid 2-[[3-(3-chloro-phenyl)-2-hydroxy-3-(2-methoxy-phenoxy)-propyl]-(4-nitro-benzenesulfonyl)-amino]-ethyl ester (863969-86-2)

Guidance literature:

Multi-step reaction with 6 steps

1: Et₃N / ethyl acetate / 0.25 h / -20 °C

2: Et₃N / ethyl acetate / 0.25 h / -20 °C

3: aq. HCl / ethyl acetate / -20 - 20 °C

4: aq. NaOH; methyltributylammonium chloride / toluene / 20 °C

5: 48 percent / propan-2-ol / Heating

6: Et₃N / CH₂Cl₂

With hydrogenchloride; sodium hydroxide; triethylamine; methyl tributylammonium chloride; In dichloromethane; ethyl acetate; isopropyl alcohol; toluene;

DOI:10.1016/j.tetasy.2005.06.012

upstream raw materials:

[3-(3-chlorophenyl)-2-hydroxy-3-(2-methoxyphenoxy)]-(1-hydroxyethylamino)propane

4-Nitrobenzenesulfonyl chloride

rac-(3-(3-chlorophenyl)oxiran-2-yl)methanol

1,2-epoxy-3-[(3-chlorophenyl)-(2-methoxyphenoxy)]propane