2-Oxo-1,2-diphenylethyl phenylacetate

Base Information

• Chemical Name: 2-Oxo-1,2-diphenylethyl phenylacetate
• CAS No.: 6340-81-4
• Molecular Formula: C22H18 O3
• Molecular Weight: 330.38
• Hs Code.: 2916399090
• NSC Number: 51073
• DSSTox Substance ID: DTXSID10287441
• Mol file: 6340-81-4.mol

Synonyms:6340-81-4;2-oxo-1,2-diphenylethyl phenylacetate;NSC51073;DTXSID10287441;NSC-51073

Chemical Property of 2-Oxo-1,2-diphenylethyl phenylacetate

Chemical Property:

• Vapor Pressure: 1.86E-09mmHg at 25°C
• Boiling Point: 482.2°C at 760 mmHg
• Flash Point: 211.4°C
• PSA: 43.37000
• Density: 1.181g/cm³
• LogP: 4.39650
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 330.125594432
• Heavy Atom Count: 25
• Complexity: 427

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(=O)OC(C2=CC=CC=C2)C(=O)C3=CC=CC=C3

Technology Process of 2-Oxo-1,2-diphenylethyl phenylacetate

There total 2 articles about 2-Oxo-1,2-diphenylethyl phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

phenylacetic acid (103-82-2) + 2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) → 2-oxo-1,2-diphenylethyl 2-phenylacetate (6340-81-4)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 6h;

DOI:10.1021/ol0624530

Reference yield:

2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) + phenylacetyl chloride (103-80-0) → 2-oxo-1,2-diphenylethyl 2-phenylacetate (6340-81-4)

Guidance literature:

Reference yield: 94.0%

2-oxo-1,2-diphenylethyl 2-phenylacetate (6340-81-4) → 2-benzyl-4,5-diphenyloxazole (97015-38-8)

Guidance literature:

With ammonium acetate; acetic acid; for 2h; Heating;

DOI:10.1021/ol0624530

upstream raw materials:

2-hydroxy-2-phenylacetophenone

phenylacetyl chloride

phenylacetic acid

Downstream raw materials:

2-benzyl-4,5-diphenyloxazole

2,3,4-triphenyl-2-buten-4-olide

N-(2-phenylacetyl)benzamide

Refernces

• 1、 Meanwell,Rosenfeld,Wright,Brassard,Buchanan,Federici,Fleming,Gamberdella,Hartl,Zavoico,Seiler. "Nonprostanoid prostacyclin mimetics. 4. Derivatives of 2-[3-[2-(4,5- diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid substituted α to the oxazole ring". . p. 3871 - 3883. Retrieved 2007/10/02.