97015-38-8Relevant academic research and scientific papers
Iron-Catalyzed Cycloaddition of Amides and 2,3-Diaryl-2 H-azirines to Access Oxazoles via C-N Bond Cleavage
Zhao, Mi-Na,Ning, Gui-Wan,Yang, De-Suo,Fan, Ming-Jin,Zhang, Sheng,Gao, Peng,Zhao, Li-Fang
, p. 2957 - 2964 (2021/02/01)
A novel and efficient iron-catalyzed cycloaddition reaction using readily available 2,3-diaryl-2H-azirines and primary amides is reported. A wide range of trisubstituted oxazoles could be achieved in good yields with good functional group compatibility. In this transformation, two C-N bonds were cleaed and new C-N and C-O bonds were formed.
Copper-Catalyzed [2 + 3] Cyclization of α-Hydroxyl Ketones and Arylacetonitriles: Access to Multisubstituted Butenolides and Oxazoles
Qi, Chaorong,Peng, Youbin,Wang, Lu,Ren, Yanwei,Jiang, Huanfeng
, p. 11926 - 11935 (2018/09/25)
A copper-catalyzed [2 + 3] formal cyclization reaction between α-hydroxyl ketones and arylacetonitriles has been developed. The reaction outcome was ultimately dependent on the structure of the α-hydroxy ketones employed. Tertiary α-hydroxy ketones gave 3,4,5,5-tetrasubstituted butenolides as the sole products, while secondary α-hydroxy ketones furnished 2,4,5-trisubstituted oxazoles selectively. This method has many advantages, such as the use of easily available substrates, broad substrate scope, good functional tolerance, and milder reaction conditions.
Ceric ammonium nitrate promoted oxidation of oxazoles
Evans, David A.,Nagorny, Pavel,Xu, Risheng
, p. 5669 - 5671 (2007/10/03)
The ceric ammonium nitrate promoted oxidations of 4,5-diphenyloxazoles and oxazoles with various substitution patterns have been investigated. This transformation results in the formation of the corresponding imide in good yield and tolerates a wide variety of functional groups and substituents on the oxazole moiety.
Nonprostanoid prostacyclin mimetics. 4. Derivatives of 2-[3-[2-(4,5- diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid substituted α to the oxazole ring
Meanwell,Rosenfeld,Wright,Brassard,Buchanan,Federici,Fleming,Gamberdella,Hartl,Zavoico,Seiler
, p. 3871 - 3883 (2007/10/02)
The 4,5-diphenyloxazole derivatives 2-4 were previously identified as nonprostanoid prostacyclin (PGI2) mimetics. A series of derivatives of 2-4 bearing substitutents at the carbon atom α to the oxazole ring were synthesized and evaluated as in
