2-<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>amino>-1-methylethyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Base Information

Chemical Name:2-<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>amino>-1-methylethyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
CAS No.:122048-18-4
Molecular Formula:C₂₆H₃₂N₄O₅S
Molecular Weight:512.63
Hs Code.:

2-<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>amino>-1-methylethyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

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Chemical Property of 2-<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>amino>-1-methylethyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

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Technology Process of 2-<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>amino>-1-methylethyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

There total 4 articles about 2-<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>amino>-1-methylethyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: <2S-(2α,5α,6β)>-3-<<<2-<<<3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>hept-2-yl>carbonyl>oxy>propyl>amino>carbonyl>-1-methylpyridinium iodide

: 122048-18-4
2-<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>amino>-1-methylethyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: With sodium dithionite; sodium hydrogencarbonate; In water; ethyl acetate; for 1h;
DOI:10.1021/jm00128a019

Reference yield:

: 122048-21-9
N-(2-hydroxypropyl)-3-pyridinecarboxamide

: 122048-18-4
2-<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>amino>-1-methylethyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.85 g / dicyclohexylcarbodiimide, (dimethylamino)pyridine / acetonitrile / 60 h / 20 - 25 °C

2: 0.6 g / nitromethane / 144 h / 20 - 25 °C

3: 0.1 g / Na₂S₂O₄, NaHCO₃ / H₂O; ethyl acetate / 1 h

With dmap; sodium dithionite; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In nitromethane; water; ethyl acetate; acetonitrile;
DOI:10.1021/jm00128a019

Reference yield:

: 61-33-6
penicillin G

: 122048-18-4
2-<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>amino>-1-methylethyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-<(phenylacetyl)amino>-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.85 g / dicyclohexylcarbodiimide, (dimethylamino)pyridine / acetonitrile / 60 h / 20 - 25 °C

2: 0.6 g / nitromethane / 144 h / 20 - 25 °C

3: 0.1 g / Na₂S₂O₄, NaHCO₃ / H₂O; ethyl acetate / 1 h

With dmap; sodium dithionite; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In nitromethane; water; ethyl acetate; acetonitrile;
DOI:10.1021/jm00128a019