1-(2,5-Dimethoxyphenyl)ethanol

Base Information

• Chemical Name: 1-(2,5-Dimethoxyphenyl)ethanol
• CAS No.: 41038-40-8
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.219
• Hs Code.: 2909498090
• DSSTox Substance ID: DTXSID80473071
• Nikkaji Number: J1.667.797C
• Mol file: 41038-40-8.mol

Synonyms:1-(2,5-dimethoxyphenyl)ethanol;41038-40-8;MFCD08442838;SCHEMBL9027230;DTXSID80473071;1-(2,5-dimethoxyphenyl)ethan-1-ol;AKOS000125486;1-(2 pound not5-Dimethoxyphenyl)ethanol;AS-10352;SY004568;CS-0154127;FT-0690601;EN300-295591;A873169

Chemical Property of 1-(2,5-Dimethoxyphenyl)ethanol

Chemical Property:

• Vapor Pressure: 0.000274mmHg at 25°C
• Melting Point: 98-99 °C
• Boiling Point: 92.5 °C(Press: 0.3 Torr)
• PKA: 14.23±0.20(Predicted)
• Density: 1.081±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 182.094294304
• Heavy Atom Count: 13
• Complexity: 149

Purity/Quality:

97% ^*data from raw suppliers

1-(2,5-Dimethoxyphenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=C(C=CC(=C1)OC)OC)O

Technology Process of 1-(2,5-Dimethoxyphenyl)ethanol

There total 4 articles about 1-(2,5-Dimethoxyphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2',5'-dimethoxyacetophenone (1201-38-3) → 1-(2,5-bis(methoxy)phenyl)ethan-1-ol (41038-40-8,89691-64-5,120523-13-9)

Guidance literature:

With aluminum isopropoxide; isopropyl alcohol;

DOI:10.1080/10473289.2000.10464144

Reference yield:

[1-(2,5-Dimethoxy-phenyl)-ethoxy]-diphenyl-silane → 1-(2,5-bis(methoxy)phenyl)ethan-1-ol (41038-40-8,89691-64-5,120523-13-9)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; for 0.5h; Yield given; Ambient temperature;

DOI:10.1002/(SICI)1099-0682(199806)1998:6<783::AID-EJIC783>3.0.CO;2-M

Reference yield:

[1-(2,5-Dimethoxy-phenyl)-vinyloxy]-diphenyl-silane (208937-71-7) → 1-(2,5-bis(methoxy)phenyl)ethan-1-ol (41038-40-8,89691-64-5,120523-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1: p-TosOH / methanol / 0.5 h / Ambient temperature

2: KBH₄ / methanol / 15 h

With potassium borohydride; toluene-4-sulfonic acid; In methanol;

DOI:10.1002/(SICI)1099-0682(199806)1998:6<783::AID-EJIC783>3.0.CO;2-M

upstream raw materials:

2',5'-dimethoxyacetophenone

methylmagnesium bromide

2,5-dimethoxybenzaldehyde

[1-(2,5-Dimethoxy-phenyl)-vinyloxy]-diphenyl-silane

Downstream raw materials:

1,4-dimethoxy-2-vinylbenzene

2',5'-dimethoxyacetophenone

Methyl 2,2,5,5-Tetramethoxy-1,4-cyclohexadienecarboxylate

1-(2,2,5,5-Tetramethoxycyclohexadienyl)ethanol