Technology Process of N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide 2,2,2-Trifluoroacetate
There total 5 articles about N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide 2,2,2-Trifluoroacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzoic acid methyl ester;
With
hydroxylamine hydrochloride; sodium methylate;
In
methanol;
at 20 ℃;
for 24h;
Inert atmosphere;
trifluoroacetic acid;
In
water;
HPLC column;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / 1,4-dioxane / 0 - 60 °C
1.2: pH 12
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere
2.2: 2 h / 80 °C / Inert atmosphere
3.1: hydroxylamine hydrochloride; sodium methylate / methanol / 24 h / 20 °C / Inert atmosphere
3.2: HPLC column
With
sulfuric acid; hydroxylamine hydrochloride; potassium tert-butylate; sodium methylate;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / 1,4-dioxane / 0 - 60 °C
1.2: pH 12
2.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere
2.2: 2 h / 80 °C / Inert atmosphere
3.1: hydroxylamine hydrochloride; sodium methylate / methanol / 24 h / 20 °C / Inert atmosphere
3.2: HPLC column
With
sulfuric acid; hydroxylamine hydrochloride; potassium tert-butylate; sodium methylate;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide;
