1-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one

Base Information

• Chemical Name: 1-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one
• CAS No.: 132609-72-4
• Molecular Formula: C₃₁H₄₇N₅O₆S₂Si₂
• Molecular Weight: 706.047

Synonyms:

Chemical Property of 1-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one

There total 3 articles about 1-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1,2,4-Triazole (288-88-0) + 1-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidine-2,4-dione (132609-70-2) → 1-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one (132609-72-4)

Guidance literature:

With trichlorophosphate;

Reference yield:

2'-O-(1,3-benzodithiol-2-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (86365-02-8) → 1-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one (132609-72-4)

Guidance literature:

Multi-step reaction with 3 steps

1: tributyltin hydride, azobisisobutyronitrile / benzene / 2 h / Heating

2: dimethylformamide / 2 h

3: 79 percent / phosphoryl chloride

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; trichlorophosphate; In N,N-dimethyl-formamide; benzene;

Reference yield:

1-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(2-mercapto-phenylsulfanylmethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidine-2,4-dione → 1-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one (132609-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide / 2 h

2: 79 percent / phosphoryl chloride

With trichlorophosphate; In N,N-dimethyl-formamide;

upstream raw materials:

1,2,4-Triazole

1-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidine-2,4-dione

2'-O-(1,3-benzodithiol-2-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

Downstream raw materials:

Dithiophosphoric acid O-[(2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

Thiophosphoric acid O-[(2R,3R,4R,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

4-Amino-1-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(2-methylsulfanyl-phenylsulfanylmethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-1H-pyrimidin-2-one

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