Technology Process of N-{(3R,4R)-3-[11-(Ethoxy-dimethyl-silanyl)-undecyl]-1,2,3,4-tetrahydro-phenanthren-4-yl}-3,5-dinitro-benzamide
There total 7 articles about N-{(3R,4R)-3-[11-(Ethoxy-dimethyl-silanyl)-undecyl]-1,2,3,4-tetrahydro-phenanthren-4-yl}-3,5-dinitro-benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 142 g / triethylamine / CH2Cl2 / 0 °C
2: 90 percent / sodium iodide, dicyclohexano-18-crown-6 / H2O / 5 h / Heating
3: 63 percent / potassium tert-butoxide / benzene / a) 40 deg C, 45 min, 2) reflux, 2 h
4: 5.9 g / sodium cyanoborohydride, ammonium acetate / propan-2-ol / 24 h / 90 - 95 °C
5: aq. sodium hydrogen carbonate / CH2Cl2 / 1 h
6: 2) triethylamine / 1) chloroplatinic acid / 1) 2-propanol, dichloromethane, reflux, 2h, 2) diethyl ether, room temperature, 30 min
With
ammonium acetate; perhydrodibenzo-18-crown-6; potassium tert-butylate; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; sodium iodide;
dihydrogen hexachloroplatinate;
In
dichloromethane; water; isopropyl alcohol; benzene;
DOI:10.1021/jo00040a026
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 63 percent / potassium tert-butoxide / benzene / a) 40 deg C, 45 min, 2) reflux, 2 h
2: 5.9 g / sodium cyanoborohydride, ammonium acetate / propan-2-ol / 24 h / 90 - 95 °C
3: aq. sodium hydrogen carbonate / CH2Cl2 / 1 h
4: 2) triethylamine / 1) chloroplatinic acid / 1) 2-propanol, dichloromethane, reflux, 2h, 2) diethyl ether, room temperature, 30 min
With
ammonium acetate; potassium tert-butylate; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine;
dihydrogen hexachloroplatinate;
In
dichloromethane; isopropyl alcohol; benzene;
DOI:10.1021/jo00040a026
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 63 percent / potassium tert-butoxide / benzene / a) 40 deg C, 45 min, 2) reflux, 2 h
2: 5.9 g / sodium cyanoborohydride, ammonium acetate / propan-2-ol / 24 h / 90 - 95 °C
3: aq. sodium hydrogen carbonate / CH2Cl2 / 1 h
4: 2) triethylamine / 1) chloroplatinic acid / 1) 2-propanol, dichloromethane, reflux, 2h, 2) diethyl ether, room temperature, 30 min
With
ammonium acetate; potassium tert-butylate; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine;
dihydrogen hexachloroplatinate;
In
dichloromethane; isopropyl alcohol; benzene;
DOI:10.1021/jo00040a026
