4-chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Base Information

Chemical Name:4-chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
CAS No.:1142947-81-6
Molecular Formula:C17H19ClN6
Molecular Weight:342.831
Hs Code.:
DSSTox Substance ID:DTXSID90705138
Wikidata:Q82637860
Mol file:1142947-81-6.mol

Synonyms:4-chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine;1142947-81-6;4-Chloro-N-[3-(4-methylpiperazin-1-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine;SCHEMBL4256785;DTXSID90705138

Suppliers and Price of 4-chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-Chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 95+%
1g
$ 987.00

Chemenu
4-chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 95%
1g
$ 931.00

Alichem
4-Chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
1g
$ 864.00

Total 5 raw suppliers

Chemical Property of 4-chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Chemical Property:

PSA：63.31000
LogP:2.53150
Storage Temp.:2-8°C
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:342.1359723
Heavy Atom Count:24
Complexity:416

Purity/Quality:

95+% ^*data from raw suppliers

4-Chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCN(CC1)C2=CC=CC(=C2)NC3=NC4=C(C=CN4)C(=N3)Cl

Technology Process of 4-chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

There total 1 articles about 4-chloro-N-(3-(4-methylpiperazin-1-yl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1142947-80-5
2-[3-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

: 1142947-81-6
(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-[3-(4-methyl-piperazin-1-yl)-phenyl]-amine

Guidance literature:: 2-[3-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol; With trichlorophosphate; at 100 ℃; for 2h;

at 0 ℃; pH=9 - 10; Alkaline aqueous solution;

Reference yield: 47.0%

: 1119899-35-2
6-cyanobenzo[b]thiophen-2-ylboronic acid

: 1142947-81-6
(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-[3-(4-methyl-piperazin-1-yl)-phenyl]-amine

: 1142947-47-4
2-(2-(3-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzo[b]thiophene-6-carbonitrile

Guidance literature:: With sodium carbonate; CyJohnPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; N,N-dimethyl-formamide; at 160 ℃; for 0.75h; Microwave irradiation;

Reference yield: 41.0%

5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl-2-boronic acid: 1078151-34-4
5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl-2-boronic acid

: 1142947-81-6
(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-[3-(4-methyl-piperazin-1-yl)-phenyl]-amine

: 1142946-99-3
tert-butyl 2-(2-{[3-(4-methylpiperazin-1-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxylate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 160 ℃; for 1h; Microwave irradiation;