4-chloro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Base Information

Chemical Name:4-chloro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
CAS No.:1142945-83-2
Molecular Formula:C18H20ClN5O
Molecular Weight:357.843
Hs Code.:
DSSTox Substance ID:DTXSID20701229
Wikidata:Q82632822
Mol file:1142945-83-2.mol

Synonyms:1142945-83-2;4-chloro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine;4-chloro-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine;4-Chloro-N-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-2-amine;SCHEMBL13883682;DTXSID20701229

Suppliers and Price of 4-chloro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
4-Chloro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 95+%
1g
$ 947.00

Chemenu
4-chloro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 95%
1g
$ 893.00

Total 7 raw suppliers

Chemical Property of 4-chloro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Chemical Property:

PSA：66.07000
LogP:3.84040
Storage Temp.:2-8°C
XLogP3:4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:357.1356380
Heavy Atom Count:25
Complexity:414

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCN(C1)CCOC2=CC=C(C=C2)NC3=NC4=C(C=CN4)C(=N3)Cl

Technology Process of 4-chloro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

There total 4 articles about 4-chloro-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1142945-82-1
2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

: 1142945-83-2
⁽⁰⁸¹⁾C₀₇₅₀₄

Guidance literature:: 2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol; With trichlorophosphate; at 120 ℃; for 0.333333h;

at 0 ℃; pH=9 - 10; Alkaline aqueous solution;

Reference yield:

: 50609-01-3
4-(2-pyrrolidinoethoxy)aniline

: 1142945-83-2
⁽⁰⁸¹⁾C₀₇₅₀₄

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide / 17 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

2.2: 0.5 h / 160 °C / Microwave irradiation

3.1: trichlorophosphate / 0.33 h / 120 °C

3.2: 0 °C / pH 9 - 10

With trifluoroacetic acid; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 52133-67-2
ethyl 2-cyano-4,4-diethoxybutyrate

: 1142945-83-2
⁽⁰⁸¹⁾C₀₇₅₀₄

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

1.2: 0.5 h / 160 °C / Microwave irradiation

2.1: trichlorophosphate / 0.33 h / 120 °C

2.2: 0 °C / pH 9 - 10

With trifluoroacetic acid; trichlorophosphate; In dichloromethane;