3-(benzyloxy)-4-methoxyaniline

Base Information

• Chemical Name: 3-(benzyloxy)-4-methoxyaniline
• CAS No.: 61324-40-1
• Molecular Formula: C14H15NO2
• Molecular Weight: 229.279
• Mol file: 61324-40-1.mol

Synonyms:3-(benzyloxy)-4-methoxyaniline;3-BENZYLOXY-4-METHOXY-PHENYLAMINE;

Chemical Property of 3-(benzyloxy)-4-methoxyaniline

Chemical Property:

• Melting Point: 97-100℃
• PSA: 44.48000
• Density: 1.143
• LogP: 3.43760

Purity/Quality:

99% ^*data from raw suppliers

3-Benzyloxy-4-methoxy-phenylamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(benzyloxy)-4-methoxyaniline

There total 14 articles about 3-(benzyloxy)-4-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.9%

2-(benzyloxy)-1-methoxy-4-nitrobenzene (75167-86-1) → 3-benzyloxy-4-methoxybenzeneamine (61324-40-1)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 85 ℃; for 1.5h;

Reference yield:

1-methoxy-4-nitro-2-(pentyloxy)benzene → 3-benzyloxy-4-methoxybenzeneamine (61324-40-1)

Guidance literature:

With acetic acid; zinc; In methanol; water; at 65 ℃; for 3.5h;

Reference yield:

5-nitroguaiacol (636-93-1) → 3-benzyloxy-4-methoxybenzeneamine (61324-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. potassium carbonate; sodium iodide / 1,2-dimethoxy-ethane / 23 h / 65 °C

2: Fe; aq. NH₄Cl / methanol / 2 h / Heating

With iron; potassium carbonate; ammonium chloride; sodium iodide; In methanol; 1,2-dimethoxyethane;

DOI:10.1016/j.bmcl.2005.08.004

upstream raw materials:

2-(benzyloxy)-1-methoxy-4-nitrobenzene

5-nitroguaiacol

benzyl bromide

5-amino-2-methoxyphenol

Downstream raw materials:

1-(3-hydroxy-4-methoxy-phenyl)-3-phenyl-imidazolidin-2-one

1-(2-chloro-phenyl)-3-(3-hydroxy-4-methoxy-phenyl)-imidazolidin-2-one

1-(3-fluoro-phenyl)-3-(3-hydroxy-4-methoxy-phenyl)-imidazolidin-2-one

3-(3-fluoro-phenyl)-1-(3-hydroxy-4-methoxy-phenyl)-imidazolidine-2,4-dione

Refernces

• 1、 Beetham, Henry,Bougen-Zhukov, Nicola,Cameron, Scott A.,Evans, Gary B.,Fraser, Michael G.,Guilford, Parry J.,Harris, Lawrence D.,Luxenburger, Andreas,Schmidt, Dorian. "Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer". . p. 18114 - 18142. Retrieved 2021/12/17.
• 2、 -. "COMPLEMENT MODULATORS AND RELATED METHODS". . . Retrieved 2020/10/20.