75167-86-1

Basic information

• Product Name: 2-(benzyloxy)-1-Methoxy-4-nitrobenzene
• Synonyms: 2-(benzyloxy)-1-Methoxy-4-nitrobenzene;Benzene, 1-Methoxy-4-nitro-2-(phenylMethoxy)-;Benzene,1-methoxy-4-nitro-2-(phenylmethoxy)-（WS205035）
• CAS NO: 75167-86-1
• Molecular Formula: C₁₄H₁₃NO₄
• Molecular Weight: 259.25732
• Mol File: 75167-86-1.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(benzyloxy)-1-Methoxy-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(benzyloxy)-1-Methoxy-4-nitrobenzene(75167-86-1)
• EPA Substance Registry System: 2-(benzyloxy)-1-Methoxy-4-nitrobenzene(75167-86-1)

Safety Data

• Hazardous Substances Data: 75167-86-1(Hazardous Substances Data)

Usage

General Description

2-(benzyloxy)-1-methoxy-4-nitrobenzene is a chemical compound that consists of a benzene ring with a benzyloxy and methoxy group attached to it. Additionally, it contains a nitro group at the 4-position of the benzene ring. 2-(benzyloxy)-1-Methoxy-4-nitrobenzene is commonly used in the pharmaceutical and agrochemical industries as an intermediate for the synthesis of various drugs and pesticides. It can also be used as a reagent in organic synthesis reactions due to its electron-withdrawing nitro group. Furthermore, it is important to handle this compound with care as it is potentially hazardous and should be stored and used in accordance with proper safety protocols.

Upstream product

• 835-79-0 1-(benzyloxy)-2-methoxybenzene 
• 636-93-1 5-nitroguaiacol 
• 100-44-7 benzyl chloride 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 74-88-4 methyl iodide 
• 100-39-0 benzyl bromide 
• 861800-46-6 carbonic acid bis-(5-nitro-2-methoxy-phenyl ester) 
• 67233-85-6 sodium 5-nitroguaiacolate 

Downstream Products

• 50352-33-5 2-benzyloxy-4-nitrophenol 
• 849217-47-6 3-fluoro-4-((6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinolin-4-yl)oxy)aniline 
• 1394166-11-0 3-fluoro-4-((6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)oxy)aniline 
• 479690-10-3 3-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline 
• 347161-74-4 4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluoroaniline 

Relevant articles and documents

Synthesis and evaluation of azalamellarin N and its A-ring-modified analogues as non-covalent inhibitors of the EGFR T790M/L858R mutant

Azalamellarin N, a synthetic lactam congener of the marine natural product lamellarin N, and its A-ring-modified analogues were synthesized and evaluated as potent and non-covalent inhibitors of the drug-resistant epidermal growth factor receptor T790M/L8

Discovery of 1,6-naphthyridinone-based MET kinase inhibitor bearing quinoline moiety as promising antitumor drug candidate

A series of 1,6-naphthyridinone-based MET kinase inhibitors bearing quinoline moiety in block A were designed and synthesized based on the structures of Cabozantinib and our reported compound IV. Extensive SAR and DMPK studies led to the identification of 20j, a potent and orally bioavailable MET kinase inhibitor with favorable kinase selectivity. More importantly, 20j exhibited statistically significant tumor growth inhibition (Tumor growth inhibition/TGI of 131%, 4/6 partial regression/PR) in the U-87 MG xeograft model, which is superior to that of Cabozantinib (TGI of 97%, 2/6 PR), and significantly better than that of compound IV (TGI of 15%, 0/6 PR) at the same dose (12.5 mg/kg). Combined with favorable in vitro potency, kinase selectivity, pharmacokinetic profile and in vivo efficacy, the promising antitumor drug candidate 20j has subsequently advanced into preclinical research.

Preparation method of 7-benzyloxy-6-methoxy-4-hydroxyquinoline

The invention discloses a preparation method of 7-benzyloxy-6-methoxy-4-hydroxyquinoline. The method comprises the following steps: under the action of anhydrous p-methylbenzenesulfonic acid, carrying out condensation reaction on 3-benzyloxy-4-methoxyanil