10-chloro-5,7-dihydro-2-methyl-7-phenylpyrimido<5,4-d>benzazepin-6(6H)-one

Base Information

• Chemical Name: 10-chloro-5,7-dihydro-2-methyl-7-phenylpyrimido<5,4-d>benzazepin-6(6H)-one
• CAS No.: 87379-36-0
• Molecular Formula: C₁₉H₁₄ClN₃O
• Molecular Weight: 335.793

Synonyms:

Chemical Property of 10-chloro-5,7-dihydro-2-methyl-7-phenylpyrimido<5,4-d>benzazepin-6(6H)-one

Chemical Property:

Purity/Quality:

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Technology Process of 10-chloro-5,7-dihydro-2-methyl-7-phenylpyrimido<5,4-d>benzazepin-6(6H)-one

There total 5 articles about 10-chloro-5,7-dihydro-2-methyl-7-phenylpyrimido<5,4-d>benzazepin-6(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

diphenyliodonium iodide (2217-79-0) + 10-chloro-2-methyl-5,7-dihydropyrimido<5,4-d>benzazepin-6(6H)-one (87379-35-9) → 10-chloro-5,7-dihydro-2-methyl-7-phenylpyrimido<5,4-d>benzazepin-6(6H)-one (87379-36-0)

Guidance literature:

With sodium methylate; copper(l) chloride; In methanol; for 3h; Heating;

DOI:10.1002/jhet.5570200330

Reference yield:

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one (4424-80-0) → 10-chloro-5,7-dihydro-2-methyl-7-phenylpyrimido<5,4-d>benzazepin-6(6H)-one (87379-36-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 56 percent / chlorine / acetic acid / 2.5 h / cold water bath

2: 28.5 percent / potassium permanganate, magnesium nitrate hexahydrate / 2-methyl-propan-2-ol; H₂O / 20 h / Ambient temperature

3: 45 percent / 1 h / 115 - 120 °C

4: 90 percent / sodium methoxide / methanol / 2.5 h / Ambient temperature

5: 50 percent / cuprous chloride, sodium methoxide / methanol / 3 h / Heating

With magnesium(II) nitrate; potassium permanganate; sodium methylate; chlorine; copper(l) chloride; In methanol; water; acetic acid; tert-butyl alcohol;

DOI:10.1002/jhet.5570200330

Reference yield:

7-Chlor-1,3,4,5-tetrahydro-2H-benzazepin-2-on (22344-77-0) → 10-chloro-5,7-dihydro-2-methyl-7-phenylpyrimido<5,4-d>benzazepin-6(6H)-one (87379-36-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 28.5 percent / potassium permanganate, magnesium nitrate hexahydrate / 2-methyl-propan-2-ol; H₂O / 20 h / Ambient temperature

2: 45 percent / 1 h / 115 - 120 °C

3: 90 percent / sodium methoxide / methanol / 2.5 h / Ambient temperature

4: 50 percent / cuprous chloride, sodium methoxide / methanol / 3 h / Heating

With magnesium(II) nitrate; potassium permanganate; sodium methylate; copper(l) chloride; In methanol; water; tert-butyl alcohol;

DOI:10.1002/jhet.5570200330

upstream raw materials:

diphenyliodonium iodide

10-chloro-2-methyl-5,7-dihydropyrimido<5,4-d>benzazepin-6(6H)-one

2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one

7-Chlor-1,3,4,5-tetrahydro-2H-benzazepin-2-on

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