1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea acetate

Base Information

Chemical Name:1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea acetate
CAS No.:849217-38-5
Molecular Formula:C₂H₄O₂*C₃₃H₃₄FN₅O₄S
Molecular Weight:675.781
Hs Code.:

1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea acetate

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Chemical Property of 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea acetate

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Technology Process of 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea acetate

There total 4 articles about 1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849217-36-3
1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea

: 64-19-7,77671-22-8
acetic acid

: 849217-38-5
1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea acetate

Guidance literature:: In methanol; dichloromethane;

Reference yield:

: 849217-33-0
5-(4-chloro-6-methoxy-quinazolin-7-yloxymethyl)-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid benzyl ester

: 849217-38-5
1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

1.2: 1 - 2 h / 20 °C

2.1: ethanol; toluene / 1 - 2 h / 20 °C

3.1: hydrogen bromide; acetic acid / 1 h / 20 °C

4.1: sodium tris(acetoxy)borohydride; acetic acid / water; acetonitrile / 3 h / 0 - 20 °C

5.1: methanol; dichloromethane

With hydrogen bromide; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 29313-32-4
2-phenylacetyl isothiocyanate

: 849217-38-5
1-{3-fluoro-4-[6-methoxy-7-(2-methyl-octahydro-cyclopenta[c]pyrrole-5-ylmethoxy)-quinazolin-4-yloxy]-phenyl}-3-phenylacetyl-thiourea acetate

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol; toluene / 1 - 2 h / 20 °C

2: hydrogen bromide; acetic acid / 1 h / 20 °C

3: sodium tris(acetoxy)borohydride; acetic acid / water; acetonitrile / 3 h / 0 - 20 °C

4: methanol; dichloromethane

With hydrogen bromide; sodium tris(acetoxy)borohydride; acetic acid; In methanol; ethanol; dichloromethane; water; toluene; acetonitrile;