gadolinium(III) 2,2',2''-(10-(2-(6-(4-(3-(2-(diethylamino)-2-oxoethyl)5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Chemical Name:gadolinium(III) 2,2',2''-(10-(2-(6-(4-(3-(2-(diethylamino)-2-oxoethyl)5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
CAS No.:1419687-42-5
Molecular Formula:C₄₂H₆₀N₉O₉*Gd
Molecular Weight:992.243
Hs Code.:

gadolinium(III) 2,2',2''-(10-(2-(6-(4-(3-(2-(diethylamino)-2-oxoethyl)5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Chemical Property of gadolinium(III) 2,2',2''-(10-(2-(6-(4-(3-(2-(diethylamino)-2-oxoethyl)5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Technology Process of gadolinium(III) 2,2',2''-(10-(2-(6-(4-(3-(2-(diethylamino)-2-oxoethyl)5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

There total 7 articles about gadolinium(III) 2,2',2''-(10-(2-(6-(4-(3-(2-(diethylamino)-2-oxoethyl)5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: gadolinium(III) chloride hexahydrate

: 1419639-27-2
2,2',2''-(10-(2-((6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

: 1419687-42-5
gadolinium(III) 2,2',2''-(10-(2-(6-(4-(3-(2-(diethylamino)-2-oxoethyl)5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: With sodium hydroxide; In water; at 20 ℃; pH=6.5;
DOI:10.1002/mrc.3919

Reference yield:

: 868072-17-7
2-[2-(4'-hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

: 1419687-42-5
gadolinium(III) 2,2',2''-(10-(2-(6-(4-(3-(2-(diethylamino)-2-oxoethyl)5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / dimethyl sulfoxide / 50 °C

2: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5: sodium hydroxide / water / 20 °C / pH 6.5

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/mrc.3919

Reference yield:

: 75937-12-1
6-(Boc-amino)-1-hexanol

: 1419687-42-5
gadolinium(III) 2,2',2''-(10-(2-(6-(4-(3-(2-(diethylamino)-2-oxoethyl)5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; dmap / dichloromethane / 20 °C / Inert atmosphere

2: sodium hydroxide / dimethyl sulfoxide / 50 °C

3: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

6: sodium hydroxide / water / 20 °C / pH 6.5

With dmap; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/mrc.3919