Technology Process of Acetamide,N-[1,2,3,4,6,11-hexahydro-5,12-dihydroxy-2-(2-methyl-1,3-dioxolan-2-yl)-6,11-dioxo-2-naphthacenyl]-,(R)-
There total 13 articles about Acetamide,N-[1,2,3,4,6,11-hexahydro-5,12-dihydroxy-2-(2-methyl-1,3-dioxolan-2-yl)-6,11-dioxo-2-naphthacenyl]-,(R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
toluene;
for 4h;
Heating;
DOI:10.1021/jo00229a010
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 98.7 percent / ammonium carbonate / ethanol; H2O / 1 h / Heating
2: 92 percent / barium hydroxide octahydrate / H2O / 36 h / Heating
3: 94.9 percent / HCl (g) / 24 h / 25 °C
5: 1.) sodium hydride / 1.) THF, 65 deg C, 1.5 h, 2.) THF, 5 deg C - 10 deg C, 1 h
6: aq. sodium hydroxide, zinc / toluene / 2 h / 65 °C
7: pyridine / 1.) 20 deg C, 1 h, 2.) 70 deg C, 30 min
8: 90 percent / sodium chloride, aluminum chloride / 0.07 h / 170 °C
9: 88 percent / p-toluenesulfonic acid / toluene / 4 h / Heating
With
pyridine; ammonium carbonate; hydrogenchloride; sodium hydroxide; aluminium trichloride; barium hydroxide octahydrate; sodium hydride; toluene-4-sulfonic acid; sodium chloride; zinc;
In
ethanol; water; toluene;
DOI:10.1021/jo00229a010
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 92 percent / barium hydroxide octahydrate / H2O / 36 h / Heating
2: 94.9 percent / HCl (g) / 24 h / 25 °C
4: 1.) sodium hydride / 1.) THF, 65 deg C, 1.5 h, 2.) THF, 5 deg C - 10 deg C, 1 h
5: aq. sodium hydroxide, zinc / toluene / 2 h / 65 °C
6: pyridine / 1.) 20 deg C, 1 h, 2.) 70 deg C, 30 min
7: 90 percent / sodium chloride, aluminum chloride / 0.07 h / 170 °C
8: 88 percent / p-toluenesulfonic acid / toluene / 4 h / Heating
With
pyridine; hydrogenchloride; sodium hydroxide; aluminium trichloride; barium hydroxide octahydrate; sodium hydride; toluene-4-sulfonic acid; sodium chloride; zinc;
In
water; toluene;
DOI:10.1021/jo00229a010
