4-NITRO-PHENYLALANINE METHYL ESTER

Base Information

• Chemical Name: 4-NITRO-PHENYLALANINE METHYL ESTER
• CAS No.: 85317-52-8
• Molecular Formula: C10H12N2O4
• Molecular Weight: 224.216
• Mol file: 85317-52-8.mol

Synonyms:Methyl 4-nitrophenylalaninate;4-Nitrophenylalanine, methyl ester;

Chemical Property of 4-NITRO-PHENYLALANINE METHYL ESTER

Chemical Property:

• Vapor Pressure: 2.29E-05mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 360 °C at 760 mmHg
• PKA: 6.45±0.33(Predicted)
• Flash Point: 171.5 °C
• PSA: 98.14000
• Density: 1.283 g/cm³
• LogP: 1.86110

Purity/Quality:

98%min ^*data from raw suppliers

(S)-Methyl2-amino-3-(4-nitrophenyl)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-NITRO-PHENYLALANINE METHYL ESTER

There total 4 articles about 4-NITRO-PHENYLALANINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 4-nitrophenylalanine (1991-83-9,2922-40-9,56613-61-7,949-99-5) → methyl 2-amino-3-(4-nitrophenyl)propionate (85317-52-8)

Guidance literature:

methanol; With thionyl chloride; for 0.5h; Cooling with ice;

4-nitrophenylalanine; at 70 ℃; for 24h;

Reference yield: 90.0%

4-nitrophenylalanine (1991-83-9,2922-40-9,56613-61-7,949-99-5) → methyl 2-amino-3-(4-nitrophenyl)propionate (85317-52-8)

Guidance literature:

In methanol;

Reference yield: 82.0%

→ methyl 2-amino-3-(4-nitrophenyl)propionate (85317-52-8)

Guidance literature:

upstream raw materials:

methanol

4-nitrophenylalanine

(+)-Methyl 2-amino-3-(4-nitrophenyl)propionate hydrochloride

Downstream raw materials:

4-[2-(n-butylsulfonylamino)-2-(methoxy-carbonyl)-ethyl]-aniline

methyl α-(4-nitrobenzyl)diazoacetate

N¹-(3-amino-propyl)-3-(4-nitro-phenyl)-propane-1,2-diamine

DL-p-nitrophenylalanate N-(3-aminopropyl) amide

Refernces

• 1、 Lassoie, Marie-Agnes,Broeders, Fabienne,Collart, Philippe,Defrere, Laurent,de Laveleye-Defais, Francoise,Demaude, Thierry,Gassama, Abdoulaye,Guillaumet, Gerald,Hayez, Jean-Claude,Kiss, Laszlo,Knerr, Laurent,Nicolas, Jean-Marie,Norsikian, Stephanie,Quere, Luc,Routier, Sylvain,Verbois, Valerie,Provins, Laurent. "2,6-Quinolinyl derivatives as potent VLA-4 antagonists". . p. 142 - 146. Retrieved 2007/10/03.
• 2、 -. "2,6-QUINOLINYL AND 2,6-NAPHTHYL DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES AS VLA-4 INHIBITORS". Page/Page column 42. . Retrieved 2010/02/07.