2-Phenyl-1-(phenylmethyl)-4-piperidinone

Base Information

• Chemical Name: 2-Phenyl-1-(phenylmethyl)-4-piperidinone
• CAS No.: 167705-56-8
• Molecular Formula: C18H19NO
• Molecular Weight: 265.355
• Hs Code.: 2933399090
• Mol file: 167705-56-8.mol

Synonyms:2-Phenyl-1-(phenylmethyl)-4-piperidinone;N-Benzyl-2-phenyl-4-piperidinone;1-Benzyl-2-phenylpiperidin-4-one

Chemical Property of 2-Phenyl-1-(phenylmethyl)-4-piperidinone

Chemical Property:

• Boiling Point: 409.7±33.0 °C(Predicted)
• PKA: 6.32±0.40(Predicted)
• PSA: 20.31000
• Density: 1.121
• LogP: 3.53070
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl-2-phenylpiperidin-4-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Phenyl-1-(phenylmethyl)-4-piperidinone

There total 11 articles about 2-Phenyl-1-(phenylmethyl)-4-piperidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(E)-5-(benzylamino)-1-phenyl-1-penten-3-one (824938-70-7) → N-benzyl-2-phenyl-4-piperidinone (167705-56-8)

Guidance literature:

With aluminum oxide; cerium(III) chloride; sodium iodide; at 35 ℃; for 24h;

DOI:10.1021/jo048329g

Reference yield: 52.0%

N-benzyl-4,4-ethylenedioxy-2-phenylpiperidine → N-benzyl-2-phenyl-4-piperidinone (167705-56-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1.5h; Heating;

DOI:10.1016/0040-4020(95)98710-Y

Reference yield: 48.0%

N-benzyl-2,3-dihydro-2-phenyl-1H-pyridin-4-one (152873-62-6) → N-benzyl-2-phenyl-4-piperidinone (167705-56-8)

Guidance literature:

With L-Selectride; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1016/S0040-4020(98)00130-6

upstream raw materials:

benzaldehyde

methyl vinyl ketone

benzylamine

N-benzyl-2,3-dihydro-2-phenyl-1H-pyridin-4-one