5,6-Dimethoxypyridin-3-amine

Base Information

• Chemical Name: 5,6-Dimethoxypyridin-3-amine
• CAS No.: 79491-49-9
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.169
• Hs Code.: 2933399090
• European Community (EC) Number: 817-302-0
• DSSTox Substance ID: DTXSID70509116
• Wikidata: Q72468469
• Mol file: 79491-49-9.mol

Synonyms:5,6-Dimethoxypyridin-3-amine;79491-49-9;5,6-Dimethoxy-3-pyridinamine;SCHEMBL115432;DTXSID70509116;GWUSRFFXHVNXOZ-UHFFFAOYSA-N;MFCD20715092;AKOS016002037;AT37344;SB76495;CS-0245888;EN300-312889;Z1262665453

Chemical Property of 5,6-Dimethoxypyridin-3-amine

Chemical Property:

• Melting Point: 91-92℃ (ligroine )
• Boiling Point: 265.7 °C at 760 mmHg
• Flash Point: 114.5 °C
• PSA: 57.37000
• Density: 1.159g/cm³
• LogP: 1.26220
• Storage Temp.: 2-8°C
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 154.074227566
• Heavy Atom Count: 11
• Complexity: 121

Purity/Quality:

5,6-dimethoxypyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(N=CC(=C1)N)OC

Technology Process of 5,6-Dimethoxypyridin-3-amine

There total 8 articles about 5,6-Dimethoxypyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.8%

2,3-dimethoxy-5-nitropyridine (507473-22-5) → 3-amino-5,6-dimethoxypyridine (79491-49-9)

Guidance literature:

With iron; ammonium chloride; In ethanol; at 80 ℃; for 2h;

Reference yield:

5-chloro-1,2-dimethoxypyridine (284040-73-9) → C14H17N3O4 (1445972-45-1) + 3-amino-5,6-dimethoxypyridine (79491-49-9)

Guidance literature:

With dicyclohexyl(2',4',6'-triisopropyl-5-methoxy-3,4,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; C₅₀H₇₀NO₄PPdS; C₅₀H₇₀NO₄PPdS; dicyclohexyl(2',4',6'-triisopropyl-4-methoxy-3,5,6-trimethyl-[1,1'-biphenyl]-2-yl)phosphine; ammonia; sodium t-butanolate; In 1,4-dioxane; at 50 ℃; for 24h; Overall yield = 75 %; Inert atmosphere;

DOI:10.1021/ol401612c

Reference yield:

2-bromo-5,6-dimethoxy-3-nitropyridine (79491-48-8) → 3-amino-5,6-dimethoxypyridine (79491-49-9)

Guidance literature:

With hydrazine hydrate; palladium on activated charcoal; In ethanol; for 0.5h; Heating;

upstream raw materials:

2-bromo-5,6-dimethoxy-3-nitropyridine

3-HYDROXYPYRIDINE

2,6-dibromopyridin-3-ol

2,6-dibromo-3-methoxy-5-nitropyridine