5-Bromo-8-methoxy-2-methylquinoline

Base Information

• Chemical Name: 5-Bromo-8-methoxy-2-methylquinoline
• CAS No.: 103862-55-1
• Molecular Formula: C11H10BrNO
• Molecular Weight: 252.11
• DSSTox Substance ID: DTXSID20405811
• Nikkaji Number: J1.605.517D
• Wikidata: Q72446249
• Mol file: 103862-55-1.mol

Synonyms:5-bromo-8-methoxy-2-methylquinoline;103862-55-1;5-bromo-8-methoxy-2-methyl-quinoline;MFCD04966993;SCHEMBL681786;DTXSID20405811;MCBRCJBMVOOJFX-UHFFFAOYSA-N;AMY10960;2-Methyl-5-bromo-8-methoxyquinoline;BBL020679;STK893369;ZB0071;AKOS001476131;DS-2366;SB71730;AC-23706;CS-0152760;FT-0737017;A26259;F20610;J-517147

Chemical Property of 5-Bromo-8-methoxy-2-methylquinoline

Chemical Property:

• Melting Point: 114 ?C
• Boiling Point: 341 ?C
• PKA: 3.01±0.50(Predicted)
• Flash Point: 160 ?C
• Density: 1.455
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 250.99458
• Heavy Atom Count: 14
• Complexity: 200

Purity/Quality:

97% ^*data from raw suppliers

5-Bromo-8-methoxy-2-methylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=C(C=CC(=C2C=C1)Br)OC

Technology Process of 5-Bromo-8-methoxy-2-methylquinoline

There total 4 articles about 5-Bromo-8-methoxy-2-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

8-methoxy-2-methylquinoline (3033-80-5) → 5-bromo-8-methoxy-2-methylquinoline (103862-55-1)

Guidance literature:

With sodium hydroxide; bromine; In methanol; water; at 20 ℃; for 0.166667h;

DOI:10.1021/jo048297x

Reference yield: 82.0%

5,7-dibromo-8,8-dimethoxy-7,8-dihydroquinaldine → 5-bromo-8-methoxy-2-methylquinoline (103862-55-1)

Guidance literature:

With 1-dodecylthiol; In tetrahydrofuran; for 1h; regioselective reaction; Reflux;

DOI:10.1016/j.tet.2016.07.010

Reference yield:

2-methoxy-phenylamine (90-04-0) → 5-bromo-8-methoxy-2-methylquinoline (103862-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl; acetic acid / 3 h / 90 °C

2: 97 percent / Br₂; NaOH / H₂O; methanol / 0.17 h / 20 °C

With hydrogenchloride; sodium hydroxide; bromine; acetic acid; In methanol; water;

DOI:10.1021/jo048297x

upstream raw materials:

8-methoxy-2-methylquinoline

2-methoxy-phenylamine

2-methyl-8-quinolinol

Downstream raw materials:

5,7-dibromo-2-methylquinolin-8-ol

(E)-5-bromo-8-methoxy-2-styrylquinoline

8-hydroxy-5-(4-dimethyl-amino-phenyl)-2-methyl-quinoline

8-hydroxy-5-(phenyl)-2-methyl-quinoline

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 103862-55-1 5-BROMO-8-METHOXY-2-METHYL-QUINOLINE

Send

Send

Metric Ton KG G Pound L ML

Send

Send