3033-80-5

Basic information

• Product Name: 8-METHOXY-2-METHYLQUINOLINE
• Synonyms: 8-METHOXYQUINALDINE;8-METHOXY-2-METHYLQUINOLINE;Methoxymethylquinoline;8-Methoxy-2-methoxyquinoline;8-METHOXY-2-METHYLQUINOLINE 98+%;2-Methyl-8-Methoxyquinoline
• CAS NO: 3033-80-5
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.21
• EINECS: -0
• Product Categories: Alkoxyquinolines;Alkylquinolines;Quinolines
• Mol File: 3033-80-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 124°C
• Boiling Point: 286°Cat760mmHg
• Flash Point: 104.9°C
• Appearance: /
• Density: 1.102g/cm³
• Vapor Pressure: 0.00467mmHg at 25°C
• Refractive Index: 1.599
• PKA: 4.13±0.50(Predicted)
• CAS DataBase Reference: 8-METHOXY-2-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHOXY-2-METHYLQUINOLINE(3033-80-5)
• EPA Substance Registry System: 8-METHOXY-2-METHYLQUINOLINE(3033-80-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 3033-80-5(Hazardous Substances Data)

Usage

General Description

8-Methoxy-2-methylquinoline is a chemical compound that belongs to the class of organic compounds known as quinolines and derivatives. These are compounds containing a quinoline, which is a bicyclic compound made up of a benzene moiety connected to a pyridine moiety at two adjacent carbon atoms, which essentially is a dark yellow-green oil in its liquid form. It is known to have a strong aroma. 8-METHOXY-2-METHYLQUINOLINE has a relevance to some pharmaceutical development due to quinolines being used as a framework in the development of several therapeutic agents such as anticancer drugs, antimalarial drugs and antibiotics.

InChI:InChI=1/C11H11NO/c1-8-6-7-9-4-3-5-10(13-2)11(9)12-8/h3-7H,1-2H3

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 109-92-2 ethyl vinyl ether 
• 79204-83-4 4-(3-methoxyphenyl)-2-butanone oxime 
• 191484-58-9 (E)-4-(3-methoxyphenyl)butan-2-one oxime 

Downstream Products

• 78224-64-3 (E)-8-methoxy-2-styrylquinoline 
• 103854-64-4 8-methoxy-2-quinolinecarboxaldehyde 
• 103862-55-1 5-bromo-8-methoxy-2-methylquinoline 
• 423755-61-7 8-hydroxy-5-(phenyl)-2-methyl-quinoline 
• 1028353-74-3 8-hydroxy-5-(4-dimethyl-amino-phenyl)-2-methyl-quinoline 

Relevant articles and documents

Assembly of substituted 2-alkylquinolines by a sequential palladium-catalyzed Ci-N and Ci-C bond formation

Diversity: A range of substituted 2-alkylquinolines can be prepared in a general and efficient synthetic approach that employs mild reaction conditions (see scheme). The synthesis is based on a sequential palladium-catalyzed Ci-N and Ci-C bond formation, followed by palladium-catalyzed aromatization, and results in the formation of the desired compounds in one step. Copyright

Transformation of oximes of phenetyl ketone derivatives to quinolines and azaspirotrienones catalyzed by tetrabutylammonium perrhenate and trifluoromethanesulfonic acid

Phenethyl ketone oximes are converted to quinolines by the treatment with tetrabutylammonium perrhenate, trifluoromethanesulfonic acid, and chloranil in refluxing 1,2-dichloroethane. Azaspirotrienones can be synthesized from p-hydroxyphenethyl or 3-(p-hydroxyphenyl)propyl ketone oximes by applying the above method. Thus prepared azaspirotrienones are converted to quinolines by acid treatment.