4-[(2-Ethoxybenzoyl)amino]-1-methyl-5-propyl-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:4-[(2-Ethoxybenzoyl)amino]-1-methyl-5-propyl-1H-pyrazole-3-carboxamide
CAS No.:501120-38-3
Molecular Formula:C17H22N4O3
Molecular Weight:330.38
Hs Code.:
DSSTox Substance ID:DTXSID70452335
Wikidata:Q82272898
Mol file:501120-38-3.mol

Synonyms:501120-38-3;4-[(2-Ethoxybenzoyl)amino]-1-methyl-5-propyl-1H-pyrazole-3-carboxamide;4-[(2-ethoxybenzoyl)amino]-1-methyl-5-propylpyrazole-3-carboxamide;4-(2-Ethoxybenzamido)-1-methyl-5-propyl-1H-pyrazole-3-carboxamide;starbld0003035;DTXSID70452335;HFNOLZIPTBNLMC-UHFFFAOYSA-N;FT-0668077

Suppliers and Price of 4-[(2-Ethoxybenzoyl)amino]-1-methyl-5-propyl-1H-pyrazole-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-[(2-Ethoxybenzoyl)amino]-1-methyl-5-propyl-1H-pyrazole-3-carboxamide
10mg
$ 180.00

Total 2 raw suppliers

Chemical Property of 4-[(2-Ethoxybenzoyl)amino]-1-methyl-5-propyl-1H-pyrazole-3-carboxamide

Chemical Property:

PSA：102.73000
LogP:3.20680
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:330.16919058
Heavy Atom Count:24
Complexity:446

Purity/Quality:

>=98% ^*data from raw suppliers

4-[(2-Ethoxybenzoyl)amino]-1-methyl-5-propyl-1H-pyrazole-3-carboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC1=C(C(=NN1C)C(=O)N)NC(=O)C2=CC=CC=C2OCC

Technology Process of 4-[(2-Ethoxybenzoyl)amino]-1-methyl-5-propyl-1H-pyrazole-3-carboxamide

There total 5 articles about 4-[(2-Ethoxybenzoyl)amino]-1-methyl-5-propyl-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 134-11-2
2-ethoxybenzoic acid

: 247583-78-4
4-Amino-1-methyl-5-propyl-3-pyrazolecarboxamide

: 501120-38-3
4-(2-ethoxybenzoyl)amino-1-methyl-5-propyl-3-pyrazolecarboxamide

Guidance literature:: 2-ethoxybenzoic acid; With thionyl chloride; for 3h; Heating;

4-Amino-1-methyl-5-propyl-3-pyrazolecarboxamide; With dmap; triethylamine; In benzene; for 3h; Heating;
DOI:10.1002/jhet.5570390532

Reference yield:

: 36983-31-0
ethyl 3-butyrylpyruvate

: 501120-38-3
4-(2-ethoxybenzoyl)amino-1-methyl-5-propyl-3-pyrazolecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 0 - 5 °C

1.2: 36 percent / H₂SO₄ / 85 - 90 °C

2.1: 78 percent / H₂SO₄; HNO₃ / 90 - 95 °C

3.1: SOCl₂

3.2: 86 percent / NH₄OH; water / 3 h / 20 °C

4.1: HCl; SnCl₂; water / 20 °C

4.2: 90 percent / NaOH; water

5.1: SOCl₂ / 3 h / Heating

5.2: 88 percent / triethylamine; 4-(dimethylamino)pyridine / benzene / 3 h / Heating

With hydrogenchloride; thionyl chloride; sulfuric acid; water; nitric acid; tin(ll) chloride; In methanol;
DOI:10.1002/jhet.5570390532

Reference yield:

: 247583-70-6
1-methyl-5-propyl-1H-pyrazole-3-carboxylic acid

: 501120-38-3
4-(2-ethoxybenzoyl)amino-1-methyl-5-propyl-3-pyrazolecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 78 percent / H₂SO₄; HNO₃ / 90 - 95 °C

2.1: SOCl₂

2.2: 86 percent / NH₄OH; water / 3 h / 20 °C

3.1: HCl; SnCl₂; water / 20 °C

3.2: 90 percent / NaOH; water

4.1: SOCl₂ / 3 h / Heating

4.2: 88 percent / triethylamine; 4-(dimethylamino)pyridine / benzene / 3 h / Heating

With hydrogenchloride; thionyl chloride; sulfuric acid; water; nitric acid; tin(ll) chloride;
DOI:10.1002/jhet.5570390532