2-Benzyl-4-(α-1,2,3,4-tetrahydroisochinolinyl-2)-benzyl-isocarbostyril Hydrochlorid

Base Information

• Chemical Name: 2-Benzyl-4-(α-1,2,3,4-tetrahydroisochinolinyl-2)-benzyl-isocarbostyril Hydrochlorid
• CAS No.: 145314-70-1
• Molecular Formula: C₃₂H₂₈N₂O*ClH
• Molecular Weight: 493.048
• Mol file: 145314-70-1.mol

Synonyms:

Chemical Property of 2-Benzyl-4-(α-1,2,3,4-tetrahydroisochinolinyl-2)-benzyl-isocarbostyril Hydrochlorid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzyl-4-(α-1,2,3,4-tetrahydroisochinolinyl-2)-benzyl-isocarbostyril Hydrochlorid

There total 6 articles about 2-Benzyl-4-(α-1,2,3,4-tetrahydroisochinolinyl-2)-benzyl-isocarbostyril Hydrochlorid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzoylisoquinoline (20335-71-1) → 2-Benzyl-4-(α-1,2,3,4-tetrahydroisochinolinyl-2)-benzyl-isocarbostyril Hydrochlorid (145314-70-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 3.2 g / acetonitrile

2: 71 percent / 85percent KOH, K₃Fe(CN)6 / dimethylformamide; H₂O; toluene / 1 h

3: 68 percent / NaBH₄ / methanol

4: 97 percent / SOCl₂ / benzene / 3 h / Heating

5: 90 mg / Na₂CO₃, 5percent HCl / CH₂Cl₂ / 3 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; thionyl chloride; sodium carbonate; potassium hexacyanoferrate(III); In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;

DOI:10.1002/ardp.19923251010

Reference yield:

benzyl bromide (100-39-0) → 2-Benzyl-4-(α-1,2,3,4-tetrahydroisochinolinyl-2)-benzyl-isocarbostyril Hydrochlorid (145314-70-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 3.2 g / acetonitrile

2: 71 percent / 85percent KOH, K₃Fe(CN)6 / dimethylformamide; H₂O; toluene / 1 h

3: 68 percent / NaBH₄ / methanol

4: 97 percent / SOCl₂ / benzene / 3 h / Heating

5: 90 mg / Na₂CO₃, 5percent HCl / CH₂Cl₂ / 3 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; thionyl chloride; sodium carbonate; potassium hexacyanoferrate(III); In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; benzene;

DOI:10.1002/ardp.19923251010

Reference yield:

4-Benzoyl-2-benzyl-1-oxo-1,2-dihydroisochinolin (122377-74-6) → 2-Benzyl-4-(α-1,2,3,4-tetrahydroisochinolinyl-2)-benzyl-isocarbostyril Hydrochlorid (145314-70-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / NaBH₄ / methanol

2: 97 percent / SOCl₂ / benzene / 3 h / Heating

3: 90 mg / Na₂CO₃, 5percent HCl / CH₂Cl₂ / 3 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; sodium carbonate; In methanol; dichloromethane; benzene;

DOI:10.1002/ardp.19923251010

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

2-Benzyl-4-(α-chlorobenzyl)-isocarbostyril

3-benzoylisoquinoline

benzyl bromide