Methyl 3-broMo-5-Methylpyridine-2-carboxylate

Base Information

• Chemical Name: Methyl 3-broMo-5-Methylpyridine-2-carboxylate
• CAS No.: 1228880-68-9
• Molecular Formula: C8H8BrNO2
• Molecular Weight: 230
• Hs Code.: 2933399090
• Mol file: 1228880-68-9.mol

Synonyms:Methyl 3-broMo-5-Methylpyridine-2-carboxylate;Methyl 3-broMo-5-Methylpicolinate;2-Pyridinecarboxylic acid, 3-broMo-5-Methyl-, Methyl ester

Chemical Property of Methyl 3-broMo-5-Methylpyridine-2-carboxylate

Chemical Property:

• Boiling Point: 292.5±35.0 °C(Predicted)
• PKA: -0.61±0.10(Predicted)
• PSA: 39.19000
• Density: 1.503±0.06 g/cm3(Predicted)
• LogP: 1.93910
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

Methyl3-Bromo-5-methylpyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-broMo-5-Methylpyridine-2-carboxylate

There total 2 articles about Methyl 3-broMo-5-Methylpyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + 3-bromo-5-methyl-pyridine-2-carboxylic acid (1211515-68-2) → methyl 3-bromo-5-methylpicolinate (1228880-68-9)

Guidance literature:

With sulfuric acid; for 4h; Reflux;

DOI:10.1021/ja408917n

Reference yield: 92.0%

→ methyl 3-bromo-5-methylpicolinate (1228880-68-9)

Guidance literature:

With sulfuric acid; for 4h; Reflux;

Reference yield:

methyl 3-bromo-5-methylpicolinate (1228880-68-9) → 8-(2-hydroxyphenoxy)-6-methylindolizine-2-carbonitrile

Guidance literature:

Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 2.5 h / -78 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / neat (no solvent) / 20 °C

3: acetic anhydride / 18 h / 100 - 140 °C

4: caesium carbonate; copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione / 1,4-dioxane / 18 h / 120 °C / Sealed tube; Inert atmosphere

5: boron tribromide / dichloromethane / 3 h / -78 - 0 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; copper(l) iodide; 2,2,6,6-tetramethylheptane-3,5-dione; acetic anhydride; boron tribromide; diisobutylaluminium hydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1021/ja408917n

upstream raw materials:

methanol

3-bromo-5-methyl-pyridine-2-carboxylic acid

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